b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”136 Tissue Engineering and Nanotheranostics
conducted T 1 and T 2 -weighted images of MHNPs. Both imaging inten-
sities were enhanced by increasing the concentration of Gd as shown in
Figs. 23(c) and 23(d). Afterwards, the corresponding relaxivities r1 and
r2 were calculated to be 0.81 mM–1s–1 and 19.33 mM–1s–1. Interestingly,
this composite demonstrated better T 2 performance as compared to
common Gd–DTPA complex. Therefore, these complex hybrid struc-
tures have potential use in imaging and therapeutic applications.
Schematic illustration (Fig. 24) of Fe 5 C 2 theranostic nanoparticles
is reported by Hou et al. The prepared nanocrystals were successfully
Fig. 24. Schematic illustration of a complex structure of Fe 5 C 2 MHNPs as a tar-
geted theranostic candidate. (a) Temperature analysis curves for water and the prepared
aqueous dispersions Fe 5 C 2 MHNPs/Resovist/AuNRs with similar concentr ation
(0.5 mM Fe or Au) under continuous radiation of an 808 nm NIR laser at 2 W cm−2.
(b) T 2 MR images of Fe 5 C 2 MHNPs (upper) in comparison to Resovist (down) at
different concentrations of iron. (c) In vivo T 2 -weighted MRI of SKOV-3 tumor-
bearing mice pre and postintravenous injection of Fe 5 C 2 –ZHER2:342 and Fe 5 C 2 –PEG.
(d) MR images of untreated and treated with NIR+MHNPs. Reprinted with permis-
sion from Ref. 41.