b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”140 Tissue Engineering and Nanotheranostics
decrease this effect. Magnetic hybrids based nanotheranostic systems
can directly relate to the biological atmosphere in vivo and to the
therapeutic outcomes such as biodistribution, biodegradability and
accumulation in tumor areas. However, the studies on MNHs for
tumor diagnosis, targeting and therapy are still in the labs and have
not been implemented clinically because of some inherent problems,
such as the stability issues, biosafety and biodegradability during
scale-up production which have not been addressed. PDT and PTT
showed significant response for skin diseases but still failed at deep
tissue penetrations. Much effort is essential for efficient research of
the correct diagnosis, biosafety issues and the efficiency of drug deliv-
ery through MNHs before these theranostic nanoparticles enable
clinical trials. In general, the multifunctional MNHs are promising
candidates of MRI diagnosis and phototherapy for cancers in future.
Acknowledgments
This work was supported by the National Natural Science Foundation
of China (U1432114, 81550110258), NSFC–Guangdong Province
Joint Project on National Supercomputer Centre in Guangzhou
(NSCC-gZ) (Aiguo Wu), Key Breakthrough Program of Chinese
Academy of Sciences (KGZD-EW-T06) and the Postdoctoral Science
Foundation of China (2014M561799). Furthermore, the authors
also acknowledge Shanghai Synchrotron Radiation Facility at Line
BL15U (No. h15sr0021) used for X-ray fluorescence imaging.
References
- Kharisov BI. A review for synthesis of nanoflowers. Recent Patents on
Nanotechnology; 2. - Jin R, Cao Y, Mirkin CA, Kelly KL, Schatz GC, Zheng JG.
Photoinduced conversion of silver nanospheres to nanoprisms. Science
294 , 1901–1903 (2001). - Li G, Peng C, Zhang C, Xu Z, Shang M, Yang D, et al. Eu3+/Tb3+-
Doped La2O2CO3/La2O3 Nano/microcrystals with multiform mor-
phologies: Facile synthesis, growth mechanism, and luminescence
properties. Inorg. Chem. 49 , 10522–10525 (2010).