“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

49

Chapter 3

Three-dimensional Bioprinting

for Cartilage Regeneration

Hailin Zhu,†, Hui Gong, Qing Liu‡

and Harry Huimin Chen*,†,§

*StemEasy Biotech, Ltd. BridgeBio Park

Jiangyin, Jiangsu 214434, P. R. China

†State Key Laboratory of Biotherapy, Sichuan University

Chengdu, Sichuan 610041, P. R. China

‡Jiangyin Recongene Biomedical Technologies, Co. Ltd.

Jiangyin, Jiangsu 214437, China

§[email protected]

Abstract: Articular cartilage is hyaline cartilage which has very

limited self-repairingcapacity after its degeneration or injury.

Recently, three-dimensional (3D) bioprinting provides a promising

method for repair and regeneration of articular cartilage. Significant

progress has been made in 3D bioprinting for cartilage regeneration,

particularly in printing hydrogels in combination of cells and growth

factors. In this chapter, we reviewed recent progress in cartilage 3D

bioprinting, including the use of various cell sources and growth

factors for cartilage formation. We also discussed the challenges and

the future research directions of cartilage regeneration.

Keywords: Bioprinting, bioink, cartilage, tissue engineering,

regenerative medicine.