Tissue Engineering And Nanotheranostics

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Preface vii

have been observed to exhibit the so-called localized surface plasmonic

resonance (LSPR), responsible for the pronounced photothermal

effects. LSPR of nanoparticles is also tunable via the particle size,

shape, and microenvironment. The LSPR nanaoparticles can therefore

be utilized for design of biosensors that respond to cell protein expres-

sion and DNA hybridization.

Chapter 7 deals with nanoparticle delivery to cancer cells. In nano

therapeutics, the key is the nanoparticle delivery to cancer cells in a

targeted and controlled fashion. This chapter introduces the method-

ology that is tailored to a specific characteristic of cancer cells: an excess

of centrioles. Centrioles are structurally composed of small cylindrical

organelles lying adjacent to the nucleus, creating weak electromagnetic

field in a cell. The electromagnetic field is proportional to the excess of

centrioles providing a biomarker for magnetically charged toxic

nanoparticles. Chapter 8 gives an overview on the development of

multifunctional nanoparticles for cancer theranostics. In dealing with

complicated issues of cancer therapy, nano carriers have to be designed

according to the clinical requirements and oncological characteristics.

For a particle to function both as an imaging contrast agent and lethal

anticancer entity, various functional moieties have to be installed in a

single carrier at nanoscale. These include anticancer drugs, fluorescent

quantum dots, tumor specific ligands, and physical means for cancer

cell killing such as photothermal nanoparticles (fold and Fe3O4). As

such, the design and development of a multifunctional carrier can be

complicated by various conflicting effects. These critical issues are

addressed with currently developed new approaches.

This book is intended to serve as an informative tutorial for

non-technical specialists from fields of medicine, chemistry, materials

science, biomedical engineering, and biology. It will shed new light

on the various strategies adopted for both tissue engineering and

nanomedicine. Both undergraduate and graduate students will find

the book a valuable reference not only on biomedicine, but also on

materials synthesis. We hope these chapters will provide timely and

useful information for the progress of tissue engineering and

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