97successful regenerative response. Another fascinating aspect of HBO treated
regenerates is that when osteoclast mediated bone degradation is de-regulated, the
extended phase of bone erosion degrades the stump bone into regions that are nor-
mally non- regenerative following simple amputation , yet these digits eventually
transition to a blastema phase and regenerate the complete digit tip [ 47 ]. In some
case we have observed degradation into the P2/P3 joint with the successful regen-
eration of both joint and distal bone tissues. These observations support the counter-
intuitive conclusion that enhancing histolytic degradation of stump tissues can, in
fact, enhance regenerative capabilities.
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5 Digit Regeneration in Mammals