159
- Schäbitz W-R, Sommer C, Zoder W et al (2000) Intravenous brain-derived neurotrophic fac-
tor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal
cerebral ischemia. Stroke 31:2212–2217 - Sharma HS (2006) Post-traumatic application of brain-derived neurotrophic factor and glia-
derived neurotrophic factor on the rat spinal cord enhances neuroprotection and improves
motor function. Acta Neurochir Suppl 96:329–334. doi: 10.1007/3-211-30714-1-69 - Sharma HS (2007) A select combination of neurotrophins enhances neuroprotection and
functional recovery following spinal cord injury. Ann N Y Acad Sci 1122:95–111.
doi: 10.1196/annals.1403.007 - Ghirnikar RS, Lee YL, Eng LF (2000) Chemokine antagonist infusion attenuates cellular
infi ltration following spinal cord contusion injury in rat. J Neurosci Res 59:63–73 - Lüttichau HR, Stine J, Boesen TP et al (2000) A highly selective Cc chemokine receptor
(Ccr)8 antagonist encoded by the poxvirus molluscum contagiosum. J Exp Med 191:171– - doi: 10.1084/jem.191.1.171
- Mantovani A, Bonecchi R, Locati M (2006) Tuning infl ammation and immunity by chemo-
kine sequestration: decoys and more. Nat Rev Immunol 6:907–918. doi: 10.1038/nri1964 - Ghirnikar R, Lee Y, Li J, Eng L (1998) Chemokine inhibition in rat stab wound brain injury
using antisense oligodeoxynucleotides. Neurosci Lett 247:21–24. doi: 10.1016/S0304-
3940(98)00268-7 - Chen M-H, Ren Q-X, Yang W-F et al (2013) Infl uences of HIF-lα on Bax/Bcl-2 and VEGF
expressions in rats with spinal cord injury. Int J Clin Exp Pathol 6:2312–2322 - Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007) mir-29 regulates Mcl-1 protein expression
and apoptosis. Oncogene 26:6133–6140. doi: 10.1038/sj.onc.1210436 - Liu X-J, Zheng X-P, Zhang R et al (2015) Combinatorial effects of miR-20a and miR-29b on
neuronal apoptosis induced by spinal cord injury. Int J Clin Exp Pathol 8:3811–3818 - Hyun J, Grova M, Nejadnik H et al (2013) Enhancing in vivo survival of adipose-derived stro-
mal cells through Bcl-2 overexpression using a minicircle vector. Stem Cells Transl Med 2:690 - Pannu R, Christie DK, Barbosa E et al (2007) Post-trauma Lipitor treatment prevents endo-
thelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following
spinal cord injury. J Neurochem 101:182–200. doi: 10.1111/j.1471-4159.2006.04354.x - Iannotti CA, Clark M, Horn KP et al (2011) A combination immunomodulatory treatment
promotes neuroprotection and locomotor recovery after contusion SCI. Exp Neurol 230:3– - doi: 10.1016/j.expneurol.2010.03.010
- Abrams MB, Nilsson I, Lewandowski SA et al (2012) Imatinib enhances functional outcome
after spinal cord injury. PLoS One 7, e38760. doi: 10.1371/journal.pone.0038760 - Schaal SM, Garg M Sen, Ghosh M et al (2012) The therapeutic profi le of rolipram, PDE
target and mechanism of action as a neuroprotectant following spinal cord injury. PLoS One
7:e43634. doi: 10.1371/journal.pone.0043634 - Lee KD, Chow WN, Sato-Bigbee C et al (2009) FTY720 reduces infl ammation and promotes
functional recovery after spinal cord injury. J Neurotrauma 26:2335–2344. doi: 10.1089/
neu.2008.0840 - Paniagua RT, Sharpe O, Ho PP et al (2006) Selective tyrosine kinase inhibition by imatinib
mesylate for the treatment of autoimmune arthritis. J Clin Invest 116:2633–2642. doi: 10.1172/
JCI28546 - Su EJ, Fredriksson L, Kanzawa M et al (2015) Imatinib treatment reduces brain injury in a murine
model of traumatic brain injury. Front Cell Neurosci 9:385. doi: 10.3389/fncel.2015.00385 - Zhan Y, Krafft PR, Lekic T et al (2015) Imatinib preserves blood-brain barrier integrity follow-
ing experimental subarachnoid hemorrhage in rats. J Neurosci Res 93:94–103. doi: 10.1002/
jnr.23475 - Buttini M, Mir A, Appel K et al (1997) Lipopolysaccharide induces expression of tumour
necrosis factor alpha in rat brain: inhibition by methylprednisolone and by rolipram. Br
J Pharmacol 122:1483–1489. doi: 10.1038/sj.bjp.0701502
7 Regenerative Strategies for the Central Nervous System