161
- Arvin KL, Han BH, Du Y et al (2002) Minocycline markedly protects the neonatal brain
against hypoxic-ischemic injury. Ann Neurol 52:54–61. doi: 10.1002/ana.10242 - Wayne State University Safety and Feasibility of Minocycline in the Treatment of Traumatic
Brain Injury (2014) In: ClinicalTrials.gov [Internet]. National Library of Medicine, Bethesda.
https://clinicaltrials.gove/ct2/show/NCT01058395NLMIde - Kovesdi E, Kamnaksh A, Wingo D et al (2012) Acute minocycline treatment mitigates the
symptoms of mild blast-induced traumatic brain injury. Front Neurol. doi: 10.3389/fneur.
2012.00111 - O’Collins VE, Macleod MR, Donnan GA et al (2006) 1,026 experimental treatments in acute
stroke. Ann Neurol 59:467–477. doi: 10.1002/ana.20741 - Cobbs CS, Chen J, Greenberg DA, Graham SH (1998) Vascular endothelial growth factor
expression in transient focal cerebral ischemia in the rat. Neurosci Lett 249:79–82.
doi: 10.1016/S0304-3940(98)00377-2 - Krupinski J, Kaluza J, Kumar P et al (1994) Role of angiogenesis in patients with cerebral
ischemic stroke. Stroke 25:1794–1798. doi: 10.1161/01.STR.25.9.1794 - Brogi E, Wu T, Namiki A, Isner JM (1994) Indirect angiogenic cytokines upregulate VEGF
and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates
VEGF expression only. Circulation 90:649–652. doi: 10.1161/01.CIR.90.2.649 - Yang J-P, Liu X-F, Liu H-J et al (2008) Extracellular signal-regulated kinase involved in
NGF/VEGF-induced neuroprotective effect. Neurosci Lett 434:212–217. doi: 10.1016/j.
neulet.2008.01.078 - Yang J-P, Liu H-J, Li Y (2009) Effect of Endoplasmic Reticulum Stress in VEGF-Induced
Neuroprotection. J. Investig, Surg - Zhu W, Mao Y, Zhao Y, et al. (2005) Transplantation of Vascular Endothelial Growth Factor-
transfected Neural Stem Cells into the Rat Brain Provides Neuroprotection after Transient
Focal Cerebral Ischemia. Neurosurgery 57 - Chu K, Park K-I, Lee S-T et al (2005) Combined treatment of vascular endothelial growth
factor and human neural stem cells in experimental focal cerebral ischemia. Neurosci Res
53:384–390. doi: 10.1016/j.neures.2005.08.010 - Kaya D, Gürsoy-Özdemir Y, Yemisci M et al (2005) VEGF protects brain against focal isch-
emia without increasing blood–brain permeability when administered intracerebroventricu-
larly. J Cereb Blood Flow 25:1111–1118. doi: 10.1038/sj.jcbfm.9600109 - Lutton C, Young YW, Williams R et al (2012) Combined VEGF and PDGF treatment reduces
secondary degeneration after spinal cord injury. J Neurotrauma 29:957–970. doi: 10.1089/
neu.2010.1423 - Kim HM, Hwang DH, Lee JE et al (2009) Ex vivo VEGF delivery by neural stem cells
enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord
injury. PLoS One 4, e4987. doi: 10.1371/journal.pone.0004987 - Hicks RR, Martin VB, Zhang L, Seroogy KB (1999) Mild experimental brain injury differ-
entially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hip-
pocampus. Exp Neurol 160:469–478. doi: 10.1006/exnr.1999.7216 - De Laporte L, des Rieux A, Tuinstra HM, et al. (2011) Vascular endothelial growth factor and
fi broblast growth factor 2 delivery from spinal cord bridges to enhance angiogenesis follow-
ing injury. J Biomed Mater Res Part A 98A:372–382. doi: 10.1002/jbm.a.33112 - Liu Y, Figley S, Spratt SK et al (2010) An engineered transcription factor which activates
VEGF-A enhances recovery after spinal cord injury. Neurobiol Dis 37:384–393 - Nori S, Okada Y, Yasuda A et al (2011) Grafted human-induced pluripotent stem-cell–derived
neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl
Acad Sci 108:16825–16830 - Nakajima H, Uchida K, Yayama T et al (2010) Targeted retrograde gene delivery of brain-
derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglia after spinal
cord injury in rats. Spine (Phila Pa 1976) 35:497–504
7 Regenerative Strategies for the Central Nervous System