170
- Ebert AD, Beres AJ, Barber AE, Svendsen CN (2008) Human neural progenitor cells over-
expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson’s
disease. Exp Neurol 209:213–223. doi: 10.1016/j.expneurol.2007.09.022 - Shear DA, Tate MC, Archer DR et al (2004) Neural progenitor cell transplants promote long-
term functional recovery after traumatic brain injury. Brain Res 1026:11–22. doi: 10.1016/j.
brainres.2004.07.087 - Koutsoudaki PN, Papastefanaki F, Stamatakis A et al (2015) Neural stem/progenitor cells
differentiate into oligodendrocytes, reduce infl ammation, and ameliorate learning defi cits
after transplantation in a mouse model of traumatic brain injury. Glia. doi: 10.1002/glia.22959 - Tsukamoto A, Uchida N, Capela A et al (2013) Clinical translation of human neural stem
cells. Stem Cell Res Ther 4:102. doi: 10.1186/scrt313 - Doetsch F, Caillé I, Lim DA et al (1999) Subventricular zone astrocytes are neural stem cells
in the adult mammalian brain. Cell 97:703–716. doi: 10.1016/S0092-8674(00)80783-7 - Morshead C, Craig C, van der Kooy D (1998) In vivo clonal analyses reveal the properties of
endogenous neural stem cell proliferation in the adult mammalian forebrain. Development
125:2251–2261 - Wright LS, Prowse KR, Wallace K et al (2006) Human progenitor cells isolated from the
developing cortex undergo decreased neurogenesis and eventual senescence following expan-
sion in vitro. Exp Cell Res 312:2107–2120. doi: 10.1016/j.yexcr.2006.03.012 - Neri M, Maderna C, Ferrari D et al (2010) Robust generation of oligodendrocyte progenitors
from human neural stem cells and engraftment in experimental demyelination models in
mice. PLoS One 5, e10145. doi: 10.1371/journal.pone.0010145 - NeuralStem Inc. Human Spinal Cord Derived Neural Stem Cell Transplantation for the
Treatment of Amyotrophic Lateral Sclerosis (ALS) (2014) In: ClinicalTrials.gov [Internet].
National Library of Medicine, Bethesda. https://clinicaltrials.gov. Accessed 11 Feb 2016 - Trounson A, Thakar RG, Lomax G, Gibbons D (2011) Clinical trials for stem cell therapies.
BMC Med 9:52. doi: 10.1186/1741-7015-9-52 - Ong WY, Levine JM (1999) A light and electron microscopic study of NG2 chondroitin sul-
fate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned
rat hippocampus. Neuroscience 92:83–95. doi: 10.1016/S0306-4522(98)00751-9 - Bergles DE, Jahr CE (1997) Synaptic Activation of Glutamate Transporters in Hippocampal
Astrocytes. Neuron 19:1297–1308. doi: 10.1016/S0896-6273(00)80420-1 - Windrem MS, Nunes MC, Rashbaum WK et al (2004) Fetal and adult human oligodendro-
cyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nat Med 10:93– - doi: 10.1038/nm974
- Cavazzin C, Ferrari D, Facchetti F et al (2006) Unique expression and localization of aqua-
porin- 4 and aquaporin-9 in murine and human neural stem cells and in their glial progeny.
Glia 53:167–181. doi: 10.1002/glia.20256 - Windrem MS, Roy NS, Wang J et al (2002) Progenitor cells derived from the adult human
subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated
lesions of the rat brain. J Neurosci Res 69:966–975. doi: 10.1002/jnr.10397 - Webber DJ, van Blitterswijk M, Chandran S (2009) Neuroprotective effect of oligodendro-
cyte precursor cell transplantation in a long-term model of periventricular leukomalacia. Am
J Pathol 175:2332–2342. doi: 10.2353/ajpath.2009.090051 - Cao Q, He Q, Wang Y et al (2010) Transplantation of ciliary neurotrophic factor-expressing
adult oligodendrocyte precursor cells promotes remyelination and functional recovery after
spinal cord injury. J Neurosci 30:2989–3001. doi: 10.1523/JNEUROSCI.3174-09.2010 - Nistor GI, Totoiu MO, Haque N et al (2005) Human embryonic stem cells differentiate into
oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 49:385– - doi: 10.1002/glia.20127
- Keirstead HS, Nistor G, Bernal G et al (2005) Human embryonic stem cell-derived oligoden-
drocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord
injury. J Neurosci 25:4694–4705. doi: 10.1523/JNEUROSCI.0311-05.2005
A. Roussas et al.