Innovations_in_Molecular_Mechanisms_and_Tissue_Engineering_(Stem_Cell_Biology_and_Regenerative_Medicine)

177

CSPG. See Chondroitin sulfate proteoglycan
(CSPG)
CXCR4 , 89 , 90
Cyanoacrylic wound dressing , 95 , 96

D
Days post implantation (DPI) , 92
De novo muscle regeneration , 48–50
amphibians , 46–47
infl ammation
anurans , 49
frogs , 50
Th1 and Th2 cytokines , 49
Xenopus , 5 0
myogenic progenitor cells
blastema , 48
ECM , 48
newt and axolotls , 49
p53 signaling pathway , 48
Pax7 − MyoG + cells , 48 , 49
retinoblastoma (Rb) , 48
transcription factors (MSX1 and
MSX2) , 48
signaling pathways , 46
tissue repair , 46
wound healing and ECM , 47–48
Denervation effect , 91
Dense cartilaginous matrix , 59
Dermabond , 95 , 96
Digit , 80–93 , 95–97
amputation , 80 , 82 , 92
circumferential swelling , 87
immunostained , 90
neonatal , 82
re-differentiation , 83
unamputated mouse , 81
Digit regeneration
defect , 83
overview , 80 , 82 , 83
Distal amputation , 80
Distal hypertrophic chondrocytes , 84
Distal intramembranous bone formation , 87
Distal scab formation , 87
Dysmorphogenesis , 91

E
ECM. See Extracellular matrix (ECM)
Elastic cartilage , 58 , 60
Elastin , 58
Embryonic cartilage , 60
Embryonic chondrogenesis , 72
Embryonic development , 59 , 60

Embryonic skeletogenesis , 72

Embryonic stem cells (ESCs) , 70 , 72 , 108 , 145

Endochondral ossifi cation , 59 , 60 , 63 , 84–86 , 88

Endogenous regenerative response , 83

Endosteal-derived osteoblasts function , 88

Epimorphic regeneration , 79

ES cells. See Embryonic stem cells (ESCs)

Extracellular matrix (ECM) , 58 , 66 , 69

digestion , 41

gene expression , 49

hyaluronic acid, tenascin-C and fi bronectin , 48

MAPK cascade , 38

proteins , 42

remodeling , 45

transporter activity , 38

and wound healing , 47–48

F

Fa s gene , 65

FBLX5 , 94

Fetal regeneration , 83

FGF2. See Fibroblast growth factor2 (FGF2)

Fibroblast growth factor-2 (FGF-2) , 129 ,

135 , 136

Fibrocartilage , 58 , 60 , 70 , 86

Fibronectin , 72

Fracture calluses , 60

Fracture healing , 60

Frog limb regeneration , 61

Frogs , 64

G

Genome editing technologies , 10 , 11

Glial scar

astrocytes , 123

chABC , 123 , 124

CNS parenchyma , 123

description , 122

drug delivery, neural sprouting , 124–125

genetic engineering, CSPG levels , 124

infl ammatory response , 123

neural injury , 123

Glycosaminoglycan (GAG) , 58

H

Healing , 59 , 60 , 64 , 65

abilities , 61

cartilage

formation during embryonic development

and adult fracture , 59 , 60

in non-human mammals , 64 , 65

Index