Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, B€ottcher Y,
Olesen J, Breuer R, M€oller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I,
Re ́thelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR,
Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S,
Franke B, Strengman E, Kiemeney LA; Genetic Risk and Outcome in Psychosis (GROUP),
Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E,
Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL,
Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A,
Arango C, Costas J, J€onsson EG, Terenius L, Agartz I, Petursson H, N€othen MM,
Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K,
Collier DA (2009) Common variants conferring risk of schizophrenia. Nature 460:744–747
Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC,
Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Gogarten
SM, Worrall BB, Seshadri S, Sale MM; Genomics and Randomized Trials Network; Framing-
ham Heart Study (2014) Genome-wide meta-analysis of homocysteine and methionine metab-
olism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with
ischemic stroke. PLoS Genet 10:e1004214
Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, J€onsson B, Olesen J, Allgulander C,
Alonso J, Faravelli C, Fratiglioni L, Jennum P, Lieb R, Maercker A, van Os J, Preisig M,
Salvador-Carulla L, Simon R, Steinhausen HC (2011) The size andburden of mental disorders
and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21:655–679
Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB,
Valant V, Battey TW, Radmanesh F, Raffeld MR, Baedorf-Kassis S, Deka R, Woo JG, Martin
LJ, Haverbusch M, Moomaw CJ, Sun G, Broderick JP, Flaherty ML, Martini SR, Kleindorfer
DO, Kissela B, Comeau ME, Jagiella JM, Schmidt H, Freudenberger P, Pichler A, Enzinger C,
Hansen BM, Norrving B, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E,
Soriano C, Roquer J, Kraft P, Ayres AM, Schwab K, McCauley JL, Pera J, Urbanik A, Rost
NS, Goldstein JN, Viswanathan A, St€ogerer EM, Tirschwell DL, Selim M, Brown DL,
Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I,
Delgado P, Malik R, Dichgans M, Greenberg SM, Rothwell PM, Lindgren A, Slowik A,
Schmidt R, Langefeld CD, Rosand J; International Stroke Genetics Consortium (2014)
Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus
for Intracerebral Hemorrhage. Am J Hum Genet 94:511–521
World Health Organization (2008) The global burden of disease: 2004 Update.http://www.who.
int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf
Wu L, Shen Y, Liu X, Ma X, Xi B, Mi J, Lindpaintner K, Tan X, Wang X (2009) The 1425G/A
SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese
population. Stroke 40:2973–2976
Yuan M, Siegel C, Zeng Z, Li J, Liu F, McCullough LD (2009) Sex differences in the response to
activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. Exp Neurol
217:210–218
Zacchigna S, Giacca M (2014) Extra- and intracellular factors regulating cardiomyocyte prolifer-
ation in postnatal life. Cardiovasc Res. doi:10.1093/cvr/cvu057
Personalized Medicine of Central Nervous System Diseases and Disorders:... 255