Microfluidics for Biologists Fundamentals and Applications

2.2 Neurology Neurology is another field which is being explored for MF applications. MF is employed for bothin vivodeliveries o ...

slice via MF gas channels [ 21 ]. The device consists of four independent parts: the perfusion chamber, the PDMS layer, the PDMS ...

2.3 Drug Development The drug development process comprises of two phases i.e., drug discovery and drug testing. The first phase ...

2.4 Organs on Chips These are the MF devices which are used for culturing living cells in micrometer- sized chambers having a co ...

liver, brain, gut, kidney, lung, and heart [ 28 ]. For analysis of kidney transport barrier function, a simplified kidney model ...

high-density integration with a highly multiplexed microdevice. The microchannels were separated by a 10μm-thick PDMS membrane c ...

membrane that is exerted by airflow and fluidic flow respectively via the two channels separated by the membrane. The mechanical ...

experiences fluid flow and supports the growth of microbial flora without compromising human cell viability [ 34 , 36 ]. The GoC ...

extracellular matrix (ECM) and are lined by human intestinal epithelial (Caco-2) mimicking the physiology of human intestine. To ...

mouse multipotent progenitor cells, the cell-cell heterogeneity is found to be connected with cell-fate decisions [ 51 , 52 ]. T ...

Table 8.2 List of different organ on chip devices with few fabrication and operation parameters Organon chip Type of cellscultur ...

and pressure sources, one can focus the cells to the desired location. Single cells were isolated in high-density arrays compose ...

oil phase. In optical and electrical sorting of cells, high-frequency electrical fields create forces which move cells into pote ...

parallel and in a relatively short period. In one run the researchers were able to run 20 different samples (glucose and BSA) wi ...

Fig. 8.8 (A) Diagram depicting the method for patterning paper into millimeter-sized channels: (a) Use of photolithography to pa ...

3.1 Molecular Diagnostics Numerous MF systems have been used for the analysis of various molecules including DNA, RNA and other ...

Other than pathogen detection the MF PoC devices include health care devices for monitoring human health from analyzing differen ...

diseases like Alzheimer’s and cancer. They have proven to be a breakthrough technology that has rendered the analysis of protein ...

3.3 Commercial Diagnostics As the global market for PoC diagnostics is expected to grow a value of US$ 24 Billion by 2018 the po ...

levels, glucose, cardiac markers and limited immunoassays [ 81 ]. The other notice- able blood chemistry analysis LoC based syst ...