125- Kato N. Ethnic differences in genetic predisposition to hypertension. Hypertens Res Off J Jpn
Soc Hypertens. 2012;35(6):574–81. - Hong KW, Go MJ, Jin HS, Lim JE, Lee JY, Han BG, et al. Genetic variations in ATP2B1,
CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two
Korean cohorts. J Hum Hypertens. 2010;24(6):367–72. - Cooper-DeHoff RM, Johnson JA. Hypertension pharmacogenomics: in search of personal-
ized treatment approaches. Nat Rev Nephrol. 2016;12(2):110–22. - Bramlage P, Pittrow D, Wittchen HU, Kirch W, Boehler S, Lehnert H, et al. Hypertension in
overweight and obese primary care patients is highly prevalent and poorly controlled. Am
J Hypertens. 2004;17(10):904–10. - Isaksson H, Cederholm T, Jansson E, Nygren A, Ostergren J. Therapy-resistant hypertension
associated with central obesity, insulin resistance, and large muscle fibre area. Blood Press.
1993;2(1):46–52. - Hall WD. Resistant hypertension, secondary hypertension, and hypertensive crises. Cardiol
Clin. 2002;20(2):281–9. - Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. 2013 ESH/ESC
guidelines for the Management of Arterial Hypertension: the task force for the management
of arterial hypertension of the European Society of Hypertension (ESH) and of the European
Society of Cardiology (ESC). Eur Heart J. 2013;34(28):2159–219. - Romero R, Bonet J, de la Sierra A, Aguilera MT. Undiagnosed obesity in hypertension: clini-
cal and therapeutic implications. Blood Press. 2007;16(6):347–53. - Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM. Influence of weight reduction on blood
pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42(5):878–84. - Id D, Bertog SC, Ziegler AK, Hornung M, Hofmann I, Vaskelyte L, et al. Predictors of
blood pressure response: obesity is associated with a less pronounced treatment response
after renal denervation. Catheter Cardiovasc Interv Off J Soc Cardiac Angiography Interv.
2016;87:E30–8. - Stevens VJ, Obarzanek E, Cook NR, Lee IM, Appel LJ, Smith West D, et al. Long-term
weight loss and changes in blood pressure: results of the trials of hypertension prevention,
phase II. Ann Intern Med. 2001;134(1):1–11. - Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S, et al. The metabolic syn-
drome in hypertension: European society of hypertension position statement. J Hypertens.
2008;26(10):1891–900. - Simonenko VB, Goriutskii VN, Dulin PA. The role of insulin resistance in pathogenesis of
arterial hypertension. Klin Med. 2014;92(9):27–33. - Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S, et al. Mechanisms of
hypertension in the cardiometabolic syndrome. J Hypertens. 2009;27(3):441–51. - de Faria AP, Modolo R, Fontana V, Moreno H. Adipokines: novel players in resistant hyper-
tension. J Clin Hypertens (Greenwich, Conn). 2014;16(10):754–9. - Yiannikouris F, Gupte M, Putnam K, Cassis L. Adipokines and blood pressure control. Curr
Opin Nephrol Hypertens. 2010;19(2):195–200. - Bulcao C, Ferreira SR, Giuffrida FM, Ribeiro-Filho FF. The new adipose tissue and adipocy-
tokines. Curr Diabetes Rev. 2006;2(1):19–28. - Sabbatini AR, Fontana V, Laurent S, Moreno H. An update on the role of adipokines in arte-
rial stiffness and hypertension. J Hypertens. 2015;33(3):435–44. - Lago F, Dieguez C, Gomez-Reino J, Gualillo O. Adipokines as emerging mediators of
immune response and inflammation. Nat Clin Pract Rheumatol. 2007;3(12):716–24. - Antuna-Puente B, Feve B, Fellahi S, Bastard JP. Adipokines: the missing link between insulin
resistance and obesity. Diabete Metab. 2008;34(1):2–11. - Qi Y, Rathinasabapathy A, Huo T, Zhang J, Shang H, Katz A, et al. 7A.04: dl adipose stem cell
is linked to obesity, elevated inflammatory cytokines and resistant hypertension. J Hypertens.
2015;33(Suppl 1):e90.
7 Pathophysiological Insights in Resistant Hypertension