165- Grassi G, Seravalle G, Brambilla G, Buzzi S, Volpe M, Cesana F, et al. Regional differences in
sympathetic activation in lean and obese normotensive individuals with obstructive sleep
apnoea. J Hypertens. 2014;32:383–8. doi:10.1097/HJH.0000000000000034. - Lambert E, Straznicky N, Schlaich M, Esler M, Dawood T, Hotchkin E, et al. Differing pattern
of sympathoexcitation in normal-weight and obesity-related hypertension. Hypertension.
2007;50:862–8. doi:10.1161/HYPERTENSIONAHA.107.094649. - Esler M, Straznicky N, Eikelis N, Masuo K, Lambert G, Lambert E. Mechanisms of sympa-
thetic activation in obesity-related hypertension. Hypertension. 2006;48:787–96.
doi:10.1161/01.HYP.0000242642.42177.49. - Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, et al. Autonomic contribu-
tion to blood pressure and metabolism in obesity. Hypertension. 2007;49:27–33. doi:10.1161/01.
HYP.0000251679.87348.05. - Wofford MR, Anderson DC, Brown CA, Jones DW, Miller ME, Hall JE. Antihypertensive
effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects. Am
J Hypertens. 2001;14:694–8. - Thorp AA, Schlaich MP. Relevance of sympathetic nervous system activation in obesity and
metabolic syndrome. J Diabetes Res. 2015;2015:341583. doi:10.1155/2015/341583. - Grassi G, Seravalle G, Dell’Oro R, Turri C, Bolla GB, Mancia G. Adrenergic and reflex abnor-
malities in obesity-related hypertension. Hypertension. 2000;36:538–42. - McBryde FD, Abdala AP, Hendy EB, Pijacka W, Marvar P, Moraes DJ, et al. The carotid body
as a putative therapeutic target for the treatment of neurogenic hypertension. Nat Commun.
2013;4:2395. doi:10.1038/ncomms3395. - Somers VK, Mark AL, Abboud FM. Potentiation of sympathetic nerve responses to hypoxia in
borderline hypertensive subjects. Hypertension. 1988;11:608–12. - Lohmeier TE, Iliescu R, Tudorancea I, Cazan R, Cates AW, Georgakopoulos D, et al. Chronic
interactions between carotid baroreceptors and chemoreceptors in obesity hypertension.
Hypertension 2016. doi:10.1161/HYPERTENSIONAHA.116.07232. - Mark AL, Somers VK. Obesity, hypoxemia, and hypertension: mechanistic insights and thera-
peutic implications. Hypertension. 2016; doi:10.1161/HYPERTENSIONAHA.116.07338. - Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interac-
tion of neurohumoral and renal mechanisms. Circ Res. 2015;116:991–1006. doi:10.1161/
CIRCRESAHA.116.305697. - Brands MW, Hall JE, Keen HL. Is insulin resistance linked to hypertension? Clin Exp
Pharmacol Physiol. 1998;25:70–6. - Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, et al.
Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med.
2009;360:44–52. doi:10.1056/NEJMoa0803085. - Iliescu R, Lohmeier TE, Tudorancea I, Laffin L, Bakris GL. Renal denervation for the treat-
ment of resistant hypertension: review and clinical perspective. Am J Physiol Renal Physiol.
2015;309:F583–94. doi:10.1152/ajprenal.00246.2015. - Schwartz SI, Griffith LSC, Neistadt A, Hagfors N. Chronic carotid sinus nerve stimulation in
the treatment of essential hypertension. Am J Surg. 1967;114:5–15. doi:10.1016/0002-9610
(67)90034-7. - Scheffers IJ, Kroon AA, Schmidli J, Jordan J, Tordoir JJ, Mohaupt MG, et al. Novel baroreflex
activation therapy in resistant hypertension: results of a European multi-center feasibility
study. J Am Coll Cardiol. 2010;56:1254–8. doi:10.1016/j.jacc.2010.03.089. - Bisognano JD, Bakris G, Nadim MK, Sanchez L, Kroon AA, Schafer J, et al. Baroreflex acti-
vation therapy lowers blood pressure in patients with resistant hypertension: results from the
double-blind, randomized, placebo-controlled rheos pivotal trial. J Am Coll Cardiol.
2011;58:765–73. doi:10.1016/j.jacc.2011.06.008. - Bakris GL, Nadim MK, Haller H, Lovett EG, Schafer JE, Bisognano JD. Baroreflex activation
therapy provides durable benefit in patients with resistant hypertension: results of long-term
follow-up in the Rheos Pivotal Trial. J Am Soc Hypertens. 2012;6:152–8. doi:10.1016/j.
jash.2012.01.003.
10 Secondary Causes: Work-Up and Its Specificities in CKD: Influence of Autonomic...