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of chronic kidney disease. Second, patients with estimated glomerular filtration rate
below 20 ml/min/1.7 m^2 were not included. Thus, results do not apply to subjects
with advanced G4 or G5 chronic kidney disease categories.
In our opinion, at present there is no solid new evidence base from SPRINT to
modify blood pressure targets for patients with chronic kidney disease, although
expert opinion may extrapolate the results on secondary endpoints or benefits
obtained in the overall population aged 75 years or more to the elderly chronic kid-
ney disease population and support lower targets also for the nondiabetic elderly
population with mild to moderate but not sever chronic kidney disease. In this
regard, KDIGO will assess the impact of the SPRINT trial on its 2012 Blood
Pressure Guideline [ 22 ]. A report on the outcomes of the specific elderly and chronic
kidney disease population in SPRINT would be most welcomed.
Acknowledgments Grant support: ISCIII and FEDER funds CD14/00133, PI13/00047, Sociedad
Española de Nefrologia, ISCIII-RETIC REDinREN/RD012/0021, and Comunidad de Madrid
CIFRA S2010/BMD-2378. Salary support: FIS Miguel Servet to MDSN, ABS, and Joan Rodes to
BFF. Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM)
to AO.
Conflict of interest statement None reported.
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