HapMap to estimate the effective numbernof independent
SNPs [20].- Well-designed replication studies are crucial to validate or
refute the initial positive association. - Fine mapping is a process of refining the associated variants to a
credible set most likely to include the causal variant, which
requires (1) that all common SNPs in the associated region
are genotyped or imputed with high confidence, (2) very strin-
gent quality control, and (3) large sample sizes sufficient in
separating out SNPs in high LD. - Meta-analysis methodology of GWA studies has successfully
improved the power for detecting and validating disease-gene
associations in some conditions, such as type 2 diabetes. There
is a wide array of approaches, including fixed effects, random
effects, Bayesian meta-analysis, and trans-ethnic meta-analysis,
you can apply in your study for particular needs [21].
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