and haplotype maps. Bioinformatics 21
(2):263–265.https://doi.org/10.1093/bioin
formatics/bth457
- Spain SL, Barrett JC (2015) Strategies for fine-
mapping complex traits. Hum Mol Genet 24
(R1):R111–R119.https://doi.org/10.1093/
hmg/ddv260 - Distefano JK, Taverna DM (2011) Review
technological issues and experimental design
of gene association studies. Methods Mol Biol
700:3–16 - Clarke GM, Anderson CA, Pettersson FH,
Cardon LR, Morris AP, Zondervan KT
(2011) Basic statistical analysis in genetic case-
control studies. Nat Protoc 6(2):121–133.
https://doi.org/10.1038/nprot.2010.182 - Skol AD, Scott LJ et al (2006) Joint analysis is
more efficient than replication-based analysis
for two-stage genome-wide association studies.
Nat Genet 5:554–564. https://doi.org/10.
1038/ejhg.2008.12 - Turner S, Armstrong LL, Bradford Y, Carlson
CS, Crawford DC, Crenshaw AT, de
Andrade M, Doheny KF, Haines JL, Hayes G,
Jarvik G, Jiang L, Kullo IJ, Li R, Ling H, Man-
olio TA, Matsumoto M, McCarty CA, McDa-
vid AN, Mirel DB, Paschall JE, Pugh EW,
Rasmussen LV, Wilke RA, Zuvich RL, Ritchie
MD (2011) Quality control procedures for
genome-wide association studies. Curr Protoc
Hum Genet Chapter 1:Unit1 19. doi:https://
doi.org/10.1002/0471142905.hg0119s68
- Auer PL, Lettre G (2015) Rare variant associa-
tion studies: considerations, challenges and
opportunities. Genome Med 7(1):16.
https://doi.org/10.1186/s13073-015-0138-
2 - Nyholt DR (2004) A simple correction for
multiple testing for single-nucleotide poly-
morphisms in linkage disequilibrium with
each other. Am J Hum Genet 74:765–769 - Zeggini E, Ioannidis JP (2009) Meta-analysis
in genome-wide association studies. Pharma-
cogenomics 10(2):191–201.https://doi.org/
10.2217/14622416.10.2.191
108 Michelle Chang et al.