cost paths. IEEE Transactions on Systems Sci-
ence and Cybernetics 4:100–107- EW D (1959) A note on two problems in
connection with graphs. Numer Math
1:269–271 - Basso K, Margolin AA, Stolovitzky G, Klein U,
Dalla-Favera R, Califano A (2005) Reverse
engineering of regulatory networks in human
B cells. Nat Genet 37(4):382–390.https://
doi.org/10.1038/ng1532 - Butte AJ, Kohane IS (2000) Mutual informa-
tion relevance networks: functional genomic
clustering using pairwise entropy measure-
ments. Pac Symp Biocomput:418–429 - Scutari M (2010) Learning Bayesian networks
with the bnlearn R package. J Stat Softw 35
(3):1–22 - Huang T, Yang J, Cai Y-D (2015) Novel can-
didate key drivers in the integrative network of
genes, MicroRNAs, methylations, and copy
number variations in squamous cell lung carci-
noma. Biomed Res Int 2015:358125.https://
doi.org/10.1155/2015/358125
69. Huang T, Liu L, Qian Z, Tu K, Li Y, Xie L
(2010) Using GeneReg to construct time delay
gene regulatory networks. BMC Res Notes 3
(1):142. https://doi.org/10.1186/1756-
0500-3-142
70. Franceschini A, Szklarczyk D, Frankild S,
Kuhn M, Simonovic M, Roth A, Lin J,
Minguez P, Bork P, von Mering C, Jensen LJ
(2013) STRING v9.1: protein-protein interac-
tion networks, with increased coverage and
integration. Nucleic Acids Res 41(Database
issue):D808–D815. https://doi.org/10.
1093/nar/gks1094
71. Ogata H, Goto S, Sato K, Fujibuchi W,
Bono H, Kanehisa M (1999) KEGG: Kyoto
Encyclopedia of genes and genomes. Nucleic
Acids Res 27(1):29–34
72. Kamburov A, Wierling C, Lehrach H, Herwig
R (2009) ConsensusPathDB--a database for
integrating human functional interaction net-
works. Nucleic Acids Res 37(Database issue):
D623–D628.https://doi.org/10.1093/nar/
gkn698
154 Guangyong Zheng and Tao Huang