Computational Systems Biology Methods and Protocols.7z

(nextflipdebug5) #1
deletion of Ikaros. Nature 453
(7191):110–114


  1. Mullighan CG et al (2009) Deletion of
    IKZF1 and prognosis in acute lymphoblastic
    leukemia. N Engl J Med 360(5):470–480

  2. Mullighan CG et al (2009) Rearrangement of
    CRLF2 in B-progenitor–and Down syndro-
    me–associated acute lymphoblastic leukemia.
    Nat Genet 41(11):1243–1246

  3. Kawamata N et al (2008) Molecular allelokar-
    yotyping of pediatric acute lymphoblastic leu-
    kemias by high-resolution single nucleotide
    polymorphism oligonucleotide genomic
    microarray. Blood 111(2):776–784

  4. Kuiper R et al (2007) High-resolution geno-
    mic profiling of childhood ALL reveals novel
    recurrent genetic lesions affecting pathways
    involved in lymphocyte differentiation and
    cell cycle progression. Leukemia 21
    (6):1258–1266

  5. Kuiper R et al (2010) IKZF1 deletions predict
    relapse in uniformly treated pediatric precur-
    sor B-ALL. Leukemia 24(7):1258–1264

  6. Den Boer ML et al (2009) A subtype of child-
    hood acute lymphoblastic leukaemia with
    poor treatment outcome: a genome-wide
    classification study. Lancet Oncol 10
    (2):125–134

  7. Roberts KG et al (2012) Genetic alterations
    activating kinase and cytokine receptor signal-
    ing in high-risk acute lymphoblastic leukemia.
    Cancer Cell 22(2):153–166

  8. Wood B et al (2009) Patients with early T-cell
    precursor (ETP) acute lymphoblastic leuke-
    mia (ALL) have high levels of minimal resid-
    ual disease (MRD) at the end of induction—a
    Children’s Oncology Group (COG) study.
    Blood 114(22):9–9

  9. Coustan-Smith E et al (2009) Early T-cell
    precursor leukaemia: a subtype of very high-
    risk acute lymphoblastic leukaemia. Lancet
    Oncol 10(2):147–156

  10. Paugh SWet al (2015) NALP3 inflammasome
    upregulation and CASP1 cleavage of the glu-
    cocorticoid receptor cause glucocorticoid
    resistance in leukemia cells. Nat Genet 47
    (6):607–614

  11. Wang Y, Armstrong SA (2007) Genome-wide
    SNP analysis in cancer: leukemia shows the
    way. Cancer Cell 11(4):308–309

  12. Beroukhim R et al (2010) The landscape of
    somatic copy-number alteration across human
    cancers. Nature 463(7283):899–905

  13. Irving JA et al (2005) Loss of heterozygosity
    and somatic mutations of the glucocorticoid
    receptor gene are rarely found at relapse in
    pediatric acute lymphoblastic leukemia but


may occur in a subpopulation early in the
disease course. Cancer Res 65
(21):9712–9718


  1. Nebral K et al (2009) Incidence and diversity
    of PAX5 fusion genes in childhood acute lym-
    phoblastic leukemia. Leukemia 23
    (1):134–143

  2. Iacobucci I et al (2009) Identification and
    molecular characterization of recurrent geno-
    mic deletions on 7p12 in the IKZF1 gene in a
    large cohort of BCR-ABL1–positive acute
    lymphoblastic leukemia patients: on behalf of
    Gruppo Italiano Malattie Ematologiche
    dell’Adulto Acute Leukemia Working Party
    (GIMEMA AL WP). Blood 114
    (10):2159–2167

  3. Lilljebjo ̈rn H et al (2010) The correlation
    pattern of acquired copy number changes in
    164 ETV6/RUNX1-positive childhood acute
    lymphoblastic leukemias. Hum Mol Genet 19
    (16):3150–3158

  4. Russell LJ et al (2009) Deregulated expres-
    sion of cytokine receptor gene, CRLF2, is
    involved in lymphoid transformation in
    B-cell precursor acute lymphoblastic leuke-
    mia. Blood 114(13):2688–2698

  5. Yoda A et al (2010) Functional screening
    identifies CRLF2 in precursor B-cell acute
    lymphoblastic leukemia. Proc Natl Acad Sci
    107(1):252–257

  6. Mullighan CG et al (2009) JAK mutations in
    high-risk childhood acute lymphoblastic leu-
    kemia. Proc Natl Acad Sci 106
    (23):9414–9418

  7. Van Vlierberghe P et al (2006) The cryptic
    chromosomal deletion del (11)(p12p13) as a
    new activation mechanism of LMO2 in pedi-
    atric T-cell acute lymphoblastic leukemia.
    Blood 108(10):3520–3529

  8. Lahortiga I et al (2007) Duplication of the
    MYB oncogene in T cell acute lymphoblastic
    leukemia. Nat Genet 39(5):593–595

  9. Clappier E et al (2007) The C-MYB locus is
    involved in chromosomal translocation and
    genomic duplications in human T-cell acute
    leukemia (T-ALL), the translocation defining
    a new T-ALL subtype in very young children.
    Blood 110(4):1251–1261

  10. Graux C et al (2004) Fusion of NUP214 to
    ABL1 on amplified episomes in T-cell acute
    lymphoblastic leukemia. Nat Genet 36
    (10):1084

  11. Palomero T et al (2007) Mutational loss of
    PTEN induces resistance to NOTCH1 inhi-
    bition in T-cell leukemia. Nat Med 13
    (10):1203–1210


Insights of Acute Lymphoblastic Leukemia with Development of Genomic... 409
Free download pdf