- Tosello V et al (2009) WT1 mutations in
T-all. Blood 114(5):1038–1045 - Xavier RJ, Rioux JD (2008) Genome-wide
association studies: a new window into
immune-mediated diseases. Nat Rev Immu-
nol 8(8):631–643 - Sherborne AL et al (2010) Variation in
CDKN2A at 9p21.3 influences childhood
acute lymphoblastic leukemia risk. Nat Genet
42(6):492–494 - Perez-Andreu V et al (2013) Inherited
GATA3 variants are associated with Ph-like
childhood acute lymphoblastic leukemia and
risk of relapse. Nat Genet 45(12):1494–1498 - Papaemmanuil E et al (2009) Loci on 7p12.2,
10q21.2 and 14q11.2 are associated with risk
of childhood acute lymphoblastic leukemia.
Nat Genet 41(9):1006–1010 - Xu H et al (2015) Inherited coding variants at
the CDKN2A locus influence susceptibility to
acute lymphoblastic leukaemia in children.
Nat Commun 6:7553 - Perez-Andreu V et al (2015) A genome-wide
association study of susceptibility to acute
lymphoblastic leukemia in adolescents and
young adults. Blood 125(4):680–686 - Liao F et al (2016) Association between
PIP4K2A polymorphisms and acute lympho-
blastic leukemia susceptibility. Medicine (Bal-
timore) 95(18):e3542 - Xu H et al (2012) ARID5B genetic poly-
morphisms contribute to racial disparities in
the incidence and treatment outcome of
childhood acute lymphoblastic leukemia. J
Clin Oncol 30(7):751–757 - Linabery AM, Ross JA (2008) Trends in
childhood cancer incidence in the
U.S. (1992–2004). Cancer 112(2):416–432 - Dores GM et al (2012) Acute leukemia inci-
dence and patient survival among children
and adults in the United States, 2001–2007.
Blood 119(1):34–43 - Burmeister Tet al (2014) Germline variants in
IKZF1, ARID5B, and CEBPE as risk factors
for adult-onset acute lymphoblastic leukemia:
an analysis from the GMALL study group.
Haematologica 99(2):e23–e25 - Hou Q et al (2017) Regulatory network of
GATA3 in pediatric acute lymphoblastic leu-
kemia. Oncotarget 8(22):36040–36053 - Trevino LR et al (2009) Germline genomic
variants associated with childhood acute lym-
phoblastic leukemia. Nat Genet 41
(9):1001–1005 - Huang Q (2015) Genetic study of complex
diseases in the post-GWAS era. J Genet Geno-
mics 42(3):87–98 - Freedman ML et al (2011) Principles for the
post-GWAS functional characterization of
cancer risk loci. Nat Genet 43(6):513–518 - Vijayakrishnan J et al (2015) The 9p21.3 risk
of childhood acute lymphoblastic leukaemia is
explained by a rare high-impact variant in
CDKN2A. Sci Rep 5:15065 - Walsh KM et al (2015) A heritable missense
polymorphism in CDKN2A confers strong
risk of childhood acute lymphoblastic leuke-
mia and is preferentially selected during clonal
evolution. Cancer Res 75(22):4884–4894 - Studd JB et al (2017) Genetic and regulatory
mechanism of susceptibility to high-
hyperdiploid acute lymphoblastic leukaemia
at 10p21.2. Nat Commun 8:14616 - Hungate EA et al (2016) A variant at 9p21.3
functionally implicates CDKN2B in paediatric
B-cell precursor acute lymphoblastic leukae-
mia aetiology. Nat Commun 7:10635 - Yin D et al (2017) Impact of NUDT15 poly-
morphisms on thiopurines-induced myelo-
toxicity and thiopurines tolerance dose.
Oncotarget 8(8):13575–13585 - Yang JJ et al (2015) Inherited NUDT15 vari-
ant is a genetic determinant of mercaptopu-
rine intolerance in children with acute
lymphoblastic leukemia. J Clin Oncol 33
(11):1235–1242 - Moriyama T et al (2016) NUDT15 poly-
morphisms alter thiopurine metabolism and
hematopoietic toxicity. Nat Genet 48
(4):367–373 - Xu H et al (2015) Common variants in
ACYP2 influence susceptibility to cisplatin-
induced hearing loss. Nat Genet 47
(3):263–266 - Martinelli G et al (2009) IKZF1 (Ikaros)
deletions in BCR-ABL1-positive acute lym-
phoblastic leukemia are associated with short
disease-free survival and high rate of cumula-
tive incidence of relapse: a GIMEMA AL WP
report. J Clin Oncol 27(31):5202–5207 - Schwab C et al (2010) Evaluation of multi-
plex ligation-dependent probe amplification
as a method for the detection of copy number
abnormalities in B-cell precursor acute lym-
phoblastic leukemia. Genes Chromosom
Cancer 49(12):1104–1113 - JD MP et al (2001) A physical map of the
human genome. Nature 409(6822):934–941 - Collins FS, Morgan M, Patrinos A (2003)
The Human Genome Project: lessons from
large-scale biology. Science 300
(5617):286–290 - Wetterstrand KA (2013) DNA sequencing
costs: data from the NHGRI Genome
410 Heng Xu and Yang Shu