Computational Systems Biology Methods and Protocols.7z

(nextflipdebug5) #1
harbor EML4-ALK. J Clin Oncol 27
(26):4247–4253. https://doi.org/10.1200/
JCO.2009.22.6993


  1. Inamura K, Takeuchi K, Togashi Y, Hatano S,
    Ninomiya H, Motoi N, Mun MY, Sakao Y,
    Okumura S, Nakagawa K, Soda M, Choi YL,
    Mano H, Ishikawa Y, Nakagawa K (2009)
    EML4-ALK lung cancers are characterized by
    rare other mutations, a TTF-1 cell lineage, an
    acinar histology, and young onset. Mod Pathol
    22(4):508–515. https://doi.org/10.1038/
    modpathol.2009.2

  2. Soda M, Takada S, Takeuchi K, Choi YL,
    Enomoto M, Ueno T, Haruta H, Hamada T,
    Yamashita Y, Ishikawa Y, Sugiyama Y, Mano H
    (2008) A mouse model for EML4-ALK-posi-
    tive lung cancer. Proc Natl Acad Sci 105
    (50):19893–19897. https://doi.org/10.
    1073/pnas.0805381105

  3. Kim DW, Mehra R, Tan DS, Felip E, Chow
    LQ, Camidge DR, Vansteenkiste J, Sharma S,
    De Pas T, Riely GJ, Solomon BJ, Wolf J,
    Thomas M, Schuler M, Liu G, Santoro A,
    Sutradhar S, Li S, Szczudlo T, Yovine A, Shaw
    AT (2016) Activity and safety of ceritinib in
    patients with ALK-rearranged non-small-cell
    lung cancer (ASCEND-1): updated results
    from the multicentre, open-label, phase
    1 trial. Lancet Oncol 17(4):452–463.https://
    doi.org/10.1016/S1470-2045(15)00614-2

  4. Ou SH, Ahn JS, De Petris L, Govindan R, Yang
    JC, Hughes B, Lena H, Moro-Sibilot D,
    Bearz A, Ramirez SV, Mekhail T, Spira A,
    Bordogna W, Balas B, Morcos PN, Monnet A,
    Zeaiter A, Kim DW (2015) Alectinib in
    crizotinib-refractory ALK-rearranged non–-
    small-cell lung cancer: a phase II global study.
    J Clin Oncol 34(7):661–668.https://doi.org/
    10.1200/JCO.2015.63.9443.

  5. Shaw AT, Gandhi L, Gadgeel S, Riely GJ,
    Cetnar J, West H, Camidge DR, Socinski MA,
    Chiappori A, Mekhail T, Chao BH,
    Borghaei H, Gold KA, Zeaiter A,
    Bordogna W, Balas B, Puig O, Henschel V,
    Ou SH (2016) Alectinib in ALK-positive, cri-
    zotinib-resistant, non-small-cell lung cancer: a
    single-group, multicentre, phase 2 trial. Lancet
    Oncol 17(2):234–242. https://doi.org/10.
    1016/S1470-2045(15)00488-X
    71. Shaw AT, Kim DW, Mehra R, Tan DS, Felip E,
    Chow LQ, Camidge DR, Vansteenkiste J,
    Sharma S, De Pas T, Riely GJ, Solomon BJ,
    Wolf J, Thomas M, Schuler M, Liu G,
    Santoro A, Lau YY, Goldwasser M, Boral AL,
    Engelman JA (2014) Ceritinib in
    ALK-rearranged non–small-cell lung cancer.
    N Engl J Med 370(13):1189–1197.https://
    doi.org/10.1056/NEJMoa1311107.
    72. Shaw AT, Kim DW, Nakagawa K, Seto T,
    Crino ́L, Ahn MJ, De Pas T, Besse B, Solomon
    BJ, Blackhall F, Wu YL, Thomas M, O’Byrne
    KJ, Moro-Sibilot D, Camidge DR, Mok T,
    Hirsh V, Riely GJ, Iyer S, Tassell V, Polli A,
    Wilner KD, J€anne PA (2013) Crizotinib versus
    chemotherapy in advanced ALK-positive lung
    cancer. N Engl J Med 368(25):2385–2394.
    https://doi.org/10.1056/NEJMoa1214886
    73. Solomon BJ, Mok T, Kim DW, Wu YL,
    Nakagawa K, Mekhail T, Felip E,
    Cappuzzo F, Paolini J, Usari T, Iyer S,
    Reisman A, Wilner KD, Tursi J, Blackhall F,
    PROFILE 1014 Investigators (2014) First-
    line crizotinib versus chemotherapy in
    ALK-positive lung cancer. N Engl J Med 371
    (23):2167–2177. https://doi.org/10.1056/
    NEJMoa1408440
    74. Zou HY, Li Q, Lee JH, Arango ME, McDon-
    nell SR, Yamazaki S, Koudriakova TB, Alton G,
    Cui JJ, Kung PP, Nambu MD, Los G, Bender
    SL, Mroczkowski B, Christensen JG (2007) An
    orally available small-molecule inhibitor of
    c-met, PF-2341066, exhibits cytoreductive
    antitumor efficacy through antiproliferative
    and antiangiogenic mechanisms. Cancer Res
    67(9):4408–4417.https://doi.org/10.1158/
    0008-5472.CAN-06-4443
    75. Gettinger SN, Bazhenova LA, Langer CJ,
    Salgia R, Gold KA, Rosell R, Shaw AT, Weiss
    GJ, Tugnait M, Narasimhan NI, Dorer DJ,
    Kerstein D, Rivera VM, Clackson T, Haluska
    FG, Camidge DR (2016) Activity and safety of
    brigatinib in ALK-rearranged non-small-cell
    lung cancer and other malignancies: a single-
    arm, open-label, phase 1/2 trial. Lancet Oncol
    17(12):1683–1696. https://doi.org/10.
    1016/S1470-2045(16)30392-8


The Introduction and Clinical Application of Cell-Free Tumor DNA 65
Free download pdf