172 Chapter 11
Description/actionMay be used forContraindications and precautionsMonoamine oxidase Binhibitors (MAOBIs), SelegilineInhibits the actions of the enzymemonoamine oxidase B which catabolizes (breaks down) catecholamines, including dopamine, adrenaline and serotonin in the CNSMay be prescribed in cases ofcognitive dysfunction in older cats (Gunn-Moore, 2011)Should never be used in combinationwith TCAs, SSRIs or other medications including tramadol, metronidazole, prednisolone or trimethoprimMegestrol acetateA powerful progestogen (hormone)that can delay or prevent oestrus in entire female catsHas been used to treat urinespraying; however, the damaging side-effects outweigh the potential benefitsCommon serious side-effects ofweight-gain, mammary hyperplasia/neoplasia, blood dyscrasia (abnormal blood pathology) and increased risk of diabetes(Crowell-Davies and Landsberg, 2009; Gunn-Moore, 2011; DePorteret al., 2016.)Table 11.1.Continued.