Advances in the Canine Cranial Cruciate Ligament, 2nd edition

(Wang) #1
Role of Antibodies to Collagen Type I and II 91

autoimmune response stops after the rupture,
or that antibodies cannot be detected since they
are all present in immune complexes of these
antibodies and collagen. The latter situation
seems most likely. There is recentin vitrodoc-
umentation supporting the idea that CrCL rem-
nants exposed to the intrasynovial environment
have the potential to trigger further degradation
(Breshearset al. 2010).


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