Medical Therapy for Stifle Osteoarthritis 339Budsberg SC, Bartges JW. Nutrition and osteoarthri-
tis in dogs: does it help? Vet Clin North Am Small
Anim Pract 2006;36:1307–1323.
Burkholder WJ, Taylor L, Hulse DA. Weight loss to
optimal body condition increases ground reactive
force in dogs with osteoarthritis. Compend Cont
Educ Pract Vet 2000;23:74.
Canapp SO, McLaughlin RM, Hoskinson JJ,et al.
Scintigraphic evaluation of dogs with acute synovi-
tis after treatment with glucosamine hydrochloride
and chondroitin sulfate. Am J Vet Res 1999;60:1552–
1557.
Canapp SO, Cross AR, Brown MP,et al. Examina-
tion of synovial fluid and serum following intra-
venous injections of hyaluronan for the treatment
of osteoarthritis in dogs. Vet Comp Orthop Trau-
matol 2005;18:169–174.
Colucci J, Boyd M, Berthelette C,et al. Discovery
of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-
7-yl}carbonyl)amino]cyclopropyl}benzoic acid
(MF-766), a highly potent and selective EP4 antag-
onist for treating inflammatory pain. Bioorg Med
Chem Lett 2010;20:3760–3763.
Comblain F, Serisier S, Barthelemy N,et al.Review
of dietary supplements for the management of
osteoarthritis in dogs in studies from 2004 to 2014.
J Vet Pharmacol Ther 2016;39:1–15.
Comerford EJ, Tarlton JF, Innes JFet al. Metabolism
and composition of the canine anterior cruciate lig-
ament relate to difference in knee joint mechanics
and predisposition to ligament rupture. J Orthop
Res 2005;23:61–66.
Conzemius MG, Evans RB. Caregiver placebo effect
for dogs with lameness from osteoarthritis. J Am
Vet Med Assoc 2012;241:1314–1319.
Cuervo M, Rubio M, Sopena J,et al. Osteoarthritis
in dogs: a randomized study using mesenchymal
stem cells from adipose tissue and plasma rich in
growth factors. Int J Mol Sci 2014;15:13437–13460.
D’Altilio M, Peal A, Alvey M,et al. Therapeutic effi-
cacy and safety of undenatured type II collagen
singly or in combination with glucosamine and
chondroitin in arthritic dogs. Toxicol Mech Meth-
ods 2007;17:189–196.
Davies A, Hendrich J, Van Minh AT,et al.Func-
tional biology of the alpha(2)delta subunits of
voltage-gated calcium channels. Trends Pharmacol
Sci 2007;28:220–228.
Fahie MA, Ortolano GA, Guercio V,et al. A random-
ized controlled trial of the efficacy of autologous
platelet therapy for the treatment of osteoarthritis
in dogs. J Am Vet Med Assoc 2013;243:1291–1297.
Franklin SP, Cook JL. Prospective trial of autologous
conditioned plasma versus hyaluronan plus corti-
costeroid for elbow osteoarthritis in dogs. Can Vet
J 2013;54:881–884.
Frye CW, Shmalberg JW, Wakshlag JJ. Obesity, exer-
cise and orthopedic disease. Vet Clin North Am
Small Anim Pract 2016;46:831–841
Fujiki M, Shineha J, Yamanokucki K,et al. Effects
of treatment of polysulfated glycosaominoglycan
on serum cartilage olgomeric matrix protein and
C-reactive protein concentrations, serum matrix
metalloproteinase-2 and -9 activities, and lame-
ness in dogs with osteoarthritis. Am J Vet Res
2007;68:827–833.
German AJ. The growing problem of obesity in dogs
and cats. J Nutr 2006;136:1940S–1946S.
German AJ. Weight management in obese pets: the
tailoring concept and how it can improve results.
Acta Vet Scand. 2016;20:57.
Glade MJ. Polysulfated glycosaminoglycan acceler-
ates net synthesis of collagen and glycosaminogly-
cans by arthritic equine cartilage tissues and chon-
drocytes. Am J Vet Res 1990;51:779–785.
Greenberg AS, Obin MS. Obesity and the role of adi-
pose tissue in inflammation and metabolism. Am J
Clin Nutr 2006;83:S461–S465.
Guercio A, Di Marco P, Casella S,et al. Production
of canine mesenchymal stem cells from adipose
tissue and their application in dogs with chronic
osteoarthritis of the humeroradial joints. Cell Biol
Int 2012;36:189–194.
Gupta RC, Canerdy TD, Lindley J,et al. Comparative
therapeutic efficacy and safety of type-II collagen
(UC-II), glucosamine and chondroitin in arthritic
dogs: pain evaluation by ground force plate. J Anim
Physiol Anim Nutr (Berl) 2012;96:770–777.
Hadley HS, Wheeler JL, Petersen SW. Effects of intra-
articular botulinum toxin type A (Botox) in dogs
with chronic osteoarthritis. Vet Comp Orthop Trau-
matol 2010;23:254–258.
Harman R, Carlson K, Gaynor J,et al. A prospective,
randomized, masked, and placebo-controlled effi-
cacy study of intraarticular allogeneic adipose stem
cells for the treatment of osteoarthritis in dogs.
Front Vet Sci 2016;3:81.
Heikkila HM, Hielm-Bjorkman AK, Morelius M, ̈ et al.
Intra-articular botulinum toxin A for the treat-
ment of osteoarthritic joint pain in dogs: a ran-
domized, double-blinded, placebo-controlled clin-
ical trial. Vet J 2014;200:162–169.
Hellstrom LE, Carlsson C, Boucher JF, ̈ et al. Intra-
articular injections with high molecular weight
sodium hyaluronate as a therapy for canine arthri-
tis. Vet Rec 2003;153:89–90.
Hielm-Bj ̈orkman AK, Kapatkin AS, Rita HJ. Reliabil-
ity and validity of a visual analogue scale used
by owners to measure chronic pain attributable
to osteoarthritis in their dogs. Am J Vet Res
2011;72:601–607.
Hielm-Bj ̈orkman A, Roine J, Elo K, et al.An
un-commissioned randomized, placebo-controlled
double-blind study to test the effect of deep sea fish
oil as a pain reliever for dogs suffering from canine
OA. BMC Vet Res 2012;8:157.
Impellizeri JA, Tetrick MA, Muir P. Effect of weight
reduction on clinical signs of lameness in dogs