Cruciate Ligament Matrix Metabolism and Development of Laxity 71Breshears LA, Cook JL, Stoker AM,et al.Theeffect
of uniaxial cyclic tensile load on gene expression
in canine cranial cruciate ligamentocytes. Vet Surg
2010a;39:433–443.
Breshears LA, Cook JL, Stoker AM,et al. Detec-
tion and evaluation of matrix metalloproteinases
involved in cruciate ligament disease in dogs using
multiplex bead technology. Vet Surg 2010b;39:306–
314.
Cawston T. Matrix metalloproteinases and TIMPs:
properties and implications for the rheumatic dis-
eases. Mol Med Today 1998;4:130–137.
Comerford E. Evaluation of extracellular matrix com-
position, metabolism, joint mechanics and joint
conformation as potential predisposing factors of
cranial cruciate ligament rupture in three dog
breeds. Thesis, Doctor of Philosophy, University of
Bristol, 2002.
Comerford EJ, Innes JF, Tarlton JF,et al. Investigation
of the composition, turnover, and thermal proper-
ties of ruptured cranial cruciate ligaments of dogs.
Am J Vet Res 2004;65:1136–1141.
Comerford EJ, Tarlton JF, Avery NC,et al.Distal
femoral intercondylar notch dimensions and their
relationship to composition and metabolism of the
canine anterior cruciate ligament. Osteoarthritis
Cartilage 2006;14:273–278.
Comerford EJ, Tarlton JF, Innes JF,et al. Metabolism
and composition of the canine anterior cruciate lig-
ament relate to differences in knee joint mechanics
and predisposition to ligament rupture. J Orthop
Res 2005;23:61–66.
Coughlan AR, Robertson DH, Bennett D,et al.Matrix
metalloproteinases 2 and 9 in canine rheumatoid
arthritis. Vet Rec 1998;143:219–223.
Fernandes JC, Martel-Pelletier J, Lascau-Coman V,
et al. Collagenase-1 and collagenase-3 synthesis
in normal and early experimental osteoarthritic
canine cartilage: an immunohistochemical study.
J Rheumatol 1998;25:1585–1594.
Foos MJ, Hickox JR, Mansour PG,et al. Expression of
matrix metalloprotease and tissue inhibitor of met-
alloprotease genes in human anterior cruciate liga-
ment. J Orthop Res 2001;19:642–649.
FrankC,AmielD,WooSL,et al. Normal ligament
properties and ligament healing. Clin Orthop Relat
Res 1985:15–25.
Hasegawa A, Nakahara H, Kinoshita M,et al.Cel-
lular and extracellular matrix changes in anterior
cruciate ligaments during human knee aging and
osteoarthritis. Arthritis Res Ther 2013;15:R29.
Hewett TE, Zazulak BT, Myer GD. Effects of the
menstrual cycle on anterior cruciate ligament
injury risk: a systematic review. Am J Sports Med
2007;35:659–668.
Kharaz YA, Tew SR, Peffers M,et al. Proteomic dif-
ferences between native and tissue-engineered ten-
don and ligament. Proteomics 2016;16:1547–1556.
Konopka JA, DeBaun MR, Chang W,et al.Theintra-
cellular effect of relaxin on female anterior cruciate
ligament cells. Am J Sports Med 2016;44:
2384–2392.
Lee H, Petrofsky JS, Daher N,et al. Anterior cruci-
ate ligament elasticity and force for flexion during
the menstrual cycle. Med Sci Monit 2013;19:1080–
1088.
Lopez MJ, Kunz D, Vanderby R, Jr,et al. A com-
parison of joint stability between anterior cruciate
intact and deficient knees: a new canine model of
anterior cruciate ligament disruption. J Orthop Res
2003;21:224–230.
Markolf KL, Mensch JS, Amstutz HC. Stiffness and
laxity of the knee – the contributions of the support-
ing structures. A quantitativein vitrostudy. J Bone
Joint Surg Am 1976;58:583–594.
Muir P, Hayashi K, Manley PA,et al. Evaluation of
tartrate-resistant acid phosphatase and cathepsin K
in ruptured cranial cruciate ligaments in dogs. Am
J Vet Res 2002;63:1279–1284.
Muir P, Danova NA, Argyle DJ,et al. Collagenolytic
protease expression in cranial cruciate ligament
and stifle synovial fluid in dogs with cranial cru-
ciate ligament rupture. Vet Surg 2005a;34:482–490.
Muir P, Schamberger GM, Manley PA,et al.Local-
ization of cathepsin K and tartrate-resistant acid
phosphatase in synovium and cranial cruciate lig-
ament in dogs with cruciate disease. Vet Surg
2005b;34:239–246.
Nakahara H, Hasegawa A, Otabe K,et al. Tran-
scription factor Mohawk and the pathogenesis
of human anterior cruciate ligament degradation.
Arthritis Rheum 2013;65:2081–2089.
Panula HE, Lohmander LS, Ronkko S,et al. Elevated
levels of synovial fluid PLA2, stromelysin (MMP-
3) and TIMP in early osteoarthrosis after tibial val-
gus osteotomy in young beagle dogs. Acta Orthop
Scand 1998;69:152–158.
Park SK, Stefanyshyn DJ, Loitz-Ramage B,et al.
Changing hormone levels during the menstrual
cycle affect knee laxity and stiffness in healthy
female subjects. Am J Sports Med 2009;37:588–598.
Quasnichka HL, Anderson-MacKenzie JM, Tarlton
JF,et al. Cruciate ligament laxity and femoral
intercondylar notch narrowing in early-stage knee
osteoarthritis.Arthritis Rheum 2005;52:3100–3109.
Ruschke K, Meier C, Ullah M,et al. Bone mor-
phogenetic protein 2/SMAD signalling in human
ligamentocytes of degenerated and aged ante-
rior cruciate ligaments. Osteoarthritis Cartilage
2016;24:1816–1825.
Sharma L, Lou C, Felson DT, et al.Laxityin
healthy and osteoarthritic knees. Arthritis Rheum
1999;42:861–870.
Sluss JR, Liberti JP, Jiranek WA,et al. pN collagen type
III within tendon grafts used for anterior cruciate
ligament reconstruction. J Orthop Res 2001;19:852–
857.
Smith KD, Clegg PD, Innes JF,et al. Elastin content is
high in the canine cruciate ligament and is associ-
ated with degeneration. Vet J 2014;199:169–174.