116 A. Smyth and S.V. Gordon
ReferencesAagaard, C., Govaerts, M., Meikle, V., Gutierrez-Pabello, J.A., Mcnair, J., et al. (2010) Detection of bovine
tuberculosis in herds with different disease prevalence and influence of paratuberculosis infection on
PPDB and ESAT-6/CFP10 specificity. Preventive Veterinary Medicine 96, 161–169.
Abdallah, A.M., Verboom, T., Weerdenburg, E.M., Gey Van Pittius, N.C., Mahasha, P.W., et al. (2009) PPE
and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system
ESX-5. Molecular Microbiology 73, 329–340.
Alexander, K.A., Laver, P.N., Michel, A.L., Williams, M., Van Helden, P.D., et al. (2010) Novel Mycobacte-
rium tuberculosis complex pathogen, M. mungi. Emerging Infectious Diseases 16, 1296–1299.
Aranaz, A., Liebana, E., Gomez-Mampaso, E., Galan, J.C., Cousins, D., et al. (1999) Mycobacterium tuber-
culosis subsp. caprae subsp. nov.: a taxonomic study of a new member of the Mycobacterium tuber-
culosis complex isolated from goats in Spain. International Journal of Systematic Bacteriology 49(3),
1263–1273.
Arlehamn, C.S., Sidney, J., Henderson, R., Greenbaum, J.A., James, E.A., et al. (2012) Dissecting mecha-
nisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX),
Rv2654c (TB7.7), and Rv1038c (EsxJ). Journal of Immunology 188, 5020–5031.
Arruda, S., Bomfim, G., Knights, R., Huima-Byron, T. and Riley, L.W. (1993) Cloning of an M. tuberculosis
DNA fragment associated with entry and survival inside cells. Science 261, 1454–1457.
Astarie-Dequeker, C., Le Guyader, L., Malaga, W., Seaphanh, F.K., Chalut, C., et al. (2009) Phthiocerol
dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the
organization of plasma membrane lipids. PLoS Pathogens 5, e1000289.
Ates, L.S., Van Der Woude, A.D., Bestebroer, J., Van Stempvoort, G., Musters, R.J., et al. (2016) The
ESX-5 system of pathogenic mycobacteria is involved in capsule integrity and virulence through its
substrate PPE10. PLoS Pathogens 12, e1005696.
Azad, A.K., Sirakova, T.D., Fernandes, N.D. and Kolattukudy, P.E. (1997) Gene knockout reveals a novel
gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. The
Journal of Biological Chemistry 272, 16741–16745.
Banu, S., Honore, N., Saint-Joanis, B., Philpott, D., Prevost, M.C., et al. (2002) Are the PE-PGRS proteins
of Mycobacterium tuberculosis variable surface antigens? Molecular Microbiology 44, 9–19.
Berthet, F.X., Lagranderie, M., Gounon, P., Laurent-Winter, C., Ensergueix, D., et al. (1998a) Attenuation of
virulence by disruption of the Mycobacterium tuberculosis erp gene. Science 282, 759–762.
Berthet, F.X., Rasmussen, P.B., Rosenkrands, I., Andersen, P. and Gicquel, B. (1998b) A Mycobacte-
rium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein
(CFP-10). Microbiology 144(11), 3195–3203.
Bigi, F., Gioffre, A., Klepp, L., Santangelo, M.P., Velicovsky, C.A., et al. (2005) Mutation in the P36 gene of
Mycobacterium bovis provokes attenuation of the bacillus in a mouse model. Tuberculosis ( Edinburgh)
85, 221–226.
Bitter, W., Houben, E.N., Bottai, D., Brodin, P., Brown, E.J., et al. (2009) Systematic genetic nomenclature
for type VII secretion systems. PLoS Pathogens 5, e1000507.
Braunstein, M., Brown, A.M., Kurtz, S. and Jacobs Jr., W.R. (2001) Two nonredundant SecA homologues
function in mycobacteria. Journal of Bacteriology 183, 6979–6990.
Braunstein, M., Espinosa, B.J., Chan, J., Belisle, J.T. and Jacobs Jr., W.R. (2003) SecA2 functions in the
secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis. Molecular
Microbiology 48, 453–464.
Brennan, P.J. (2003) Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh) 83, 91–97.
Brennan, M.J., Delogu, G., Chen, Y., Bardarov, S., Kriakov, J., et al. (2001) Evidence that mycobacterial
PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infection
and Immunity 69, 7326–7333.
Brodin, P., Rosenkrands, I., Andersen, P., Cole, S.T. and Brosch, R. (2004) ESAT-6 proteins: protective
antigens and virulence factors? Trends in Microbiology 12, 500–508.
Brosch, R., Gordon, S.V., Marmiesse, M., Brodin, P., Buchrieser, C., et al. (2002) A new evolutionary sce-
nario for the Mycobacterium tuberculosis complex. Proceedings of the National Academy of Sciences
of the United States of America 99, 3684–3689.