Innate Immune Response in Bovine Tuberculosis 151
Kumar, H., Kawai, T. and Akira, S. (2011) Pathogen recognition by the innate immune system. International
Reviews of Immunology 30(1), 16–34.
Kumar, P., Tyagi, R., Das, G. and Bhaskar, S. (2014) Mycobacterium indicus pranii and Mycobacterium
bovis BCG lead to differential macrophage activation in Toll-like receptor-dependent manner. Immu-
nology 143(2), 258–268.
Lin, J.J., Zhao, D., Wang, J., Wang, Y., Li, H., et al. (2015) Transcriptome changes upon in vitro challenge
with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and
healthy cows. Veterinary Immunology and Immunopathology 163, 146–156.
Liu, H., Liu, Z., Chen, J., Chen, L., He, X., et al. (2013) Induction of CCL8/MCP-2 by mycobacteria through
the activation of TLR2/PI3K/Akt signaling pathway. PLoS One 8(2), e56815.
Liu, C., Yue, R., Yang, Y., Cui, Y., Yang, L., et al. (2016) AIM2 inhibits autophagy and IFN-β production during
M. bovis infection. Oncotarget 7(30), 46972–46987.
Liu, C., Xin, S., Yang, L., Zhao, D. and Zhou, X. (2017) The central role of ifi204 in ifn-beta release and
autophagy activation during Mycobacterium bovis infection. Frontiers in Cellular and Infection Micro-
biology 7, 169.
Lowe, D.M., Redford, P.S., Wilkinson, R.J., O’Garra, A. and Martineau, A.R. (2012) Neutrophils in tubercu-
losis: friend or foe? Trends in Immunology 33(1), 14–25.
Ma, Y., Han, F., Liang, J., Yang, J., Shi, J., et al. (2016) A species-specific activation of Toll-like receptor sig-
naling in bovine and sheep bronchial epithelial cells triggered by mycobacterial infections. Molecular
Immunology 71, 23–33.
Ma, J., Yang, B., Yu, S., Zhang, Y., Zhang, X., et al. (2014) Tuberculosis antigen-induced expression of
IFN-α in tuberculosis patients inhibits production of IL-1β. FASEB Journal 28, 3238–3248.
MacHugh, D.E., Gormley, E., Park, S.D.E., Browne, J.A., Taraktsoglou, M., et al. (2009) Gene expression
profiling of the host response to Mycobacterium bovis infection in cattle. Transboundary and Emerging
Diseases 56(6–7), 204–214.
Magee, D.A., Taraktsoglou, M., Killick, K.E., Nalpas, N.C., Browne, J.A., et al. (2012) Global gene expres-
sion and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro
challenge with Mycobacterium bovis. PLoS One 7(2), e32034.
Magee, D.A., Conlon, K.M., Nalpas, N.C., Browne, J.A., Pirson, C., et al. (2014) Innate cytokine profiling of
bovine alveolar macrophages reveals commonalities and divergence in the response to Mycobacte-
rium bovis and Mycobacterium tuberculosis infection. Tuberculosis 94(4), 441–450.
Manca, C., Tsenova, L., Freeman, S., Barczak, A.K., Tovey, M., et al. (2005) Hypervirulent M. tuberculosis
W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-
Stat pathway. Journal of Interferon and Cytokine Research 25, 694–701.
Mantovani, A., Cassatella, M.A., Costantini, C. and Jaillon, S. (2011) Neutrophils in the activation and regu-
lation of innate and adaptive immunity. Nature Reviews Immunology 11(8), 519–531.
Mayer-Barber, K.D., Barber, D.L., Shenderov, K., White, S.D., Wilson, M.S., et al. (2010) Caspase-1 inde-
pendent IL-1beta production is critical for host resistance to Mycobacterium tuberculosis and does not
require TLR signaling in vivo. Journal of Immunology 184(7), 3326–3330.
Mayer-Barber, K.D., Andrade, B.B., Barber, D.L., Hieny, S., Feng, C.G., et al. (2011) Innate and adaptive
interferons suppress IL-1a and IL-1b production by distinct pulmonary myeloid subsets during Myco-
bacterium tuberculosis infection. Immunity 35, 1023– 1034.
Mayer-Barber, K.D., Andrade, B.B., Oland, S.D., Amaral, E.P., Barber, D.L., et al. (2014) Host-directed ther-
apy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511(7507), 99–103.
Mishra, B.B., Moura-Alves, P., Sonawane, A., Hacohen, N., Griffiths, G., et al. (2010) Mycobacterium tuber-
culosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cellular Microbiology
12(8), 1046–1063.
Mishra, B.B., Rathinam, V.A.K., Martens, G.W., Martinot, A.J., Kornfeld, H., et al. (2012) Nitric oxide con-
trols the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing
of IL-1β. Nature Immunology 14(1), 52–60.
Mocsai, A. (2013) Diverse novel functions of neutrophils in immunity, inflammation, and beyond. Journal of
Experimental Medicine 210(7), 1283–1299.
Mortaz, E., Adcock, I.M., Tabarsi, P., Masjedi, M.R., Mansouri, D., et al. (2015) Interaction of pattern recog-
nition receptors with Mycobacterium tuberculosis. Journal of Clinical Immunology 35(1), 1–10.
Nalpas, N.C., Magee, D.A., Conlon, K.M., Browne, J.A., Healy, C., et al. (2015) RNA sequencing pro-
vides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli. Scientific
Reports 5, 13629.