258 Index
cerebrospinal fluid (CSF) 24
cervical test, single intradermal comparative (SICCT)
47, 52, 85, 175
cervids 12, 80, 97, 131, 132–133
Chad 64
vaccination 32
channel proteins 110
cheese 33, 84
cheetah 206
chemokines 127, 129, 140, 143, 149, 179, 180,
181–182, 197
children 44, 182
Mycobacterium bovis disease 22
Chile 240
cholesterol 110
chromatin condensation 145, 146
circulating biomarkers 193–196
circulating microRNA 197
circulating nucleic acid 194–195, 250
climate change 31, 48, 234
clustered regularly interspersed polymorphic repeat
(CRISPR) 61
CMI based assays 179–180
co-infection 34, 65, 162–163, 192, 250
colony forming units (CFU) 94
colostrum 240
communication 242, 253
communities, agro-pastoral 85
community leaders 240
companion animals, Mycobacterium bovis in 130
comparative cervical test (CCT) 175, 191, 192
comparative genomic analysis 177
comparative transcriptome analysis 177
compensation 35, 38, 229, 253
contagious pleuropneumonia 2
contracting 230–231
control 5, 8, 14, 18, 142, 173, 226, 228, 238, 239
border 12
challenges 252–253
developing countries 37–38
global 248–254
measures 13, 206–207, 217
mycobacteria 144–145
Mycobacterium tuberculosis 147
policies 229
programmes 17, 33, 58, 70, 206
Australia 38
industrial countries 51
Ireland 62
UK 62
strategies 36, 38, 99
zoonotic tuberculosis 12–13
CpnT proteins 110
cryptic infection, wildlife 53–54
culling 98, 99, 192, 234, 253
badgers 53, 63, 100, 215
possums 213
cultural behavioural habits 34
culture 17
cutaneous tuberculosis 21
cynomolgus macaques 129
cytokines 127, 128, 129, 134, 135, 140, 142, 143,
146–149, 155–158, 160, 161, 163, 174,
179–182, 210
serum 197–198dairy industry 17, 34
New Zealand 34
dairy products 21
unpasteurised 17, 19–20, 23, 25
DALYs (disability-adjusted life-years) 19
DAMs (damage-associated molecular patterns) 140,
144
Dassie bacillus 106
data 6, 19, 32
deaths, human tuberculosis 16, 32, 239, 249
decision makers 36, 38, 249
decision-support tools 70
deer 21, 63, 98, 183, 249
abscesses 96
BCG 212–213
hunting 94
lesions 96, 212
lymph nodes 96
lymphadenitis 96
maintenance hosts 100
Mycobacterium bovis in 96–97, 98
New Zealand 96, 99, 101
Spain 96, 101
spillover hosts 97
Sweden 64
USA 100, 213
vaccination 212–213
see also fallow deer; red deer; white-tailed deer
deer–cattle transmission 100
delayed hypersensitivity test 12
delayed-type hypersensitivity (DTH) 174
dendritic cells (DC) 140, 142–143, 146, 156, 197
density-dependent transmission 48–50, 49
developing countries 37–38
diabetes mellitus 193
diagnosis 23, 176, 184, 198, 250–251
early 14, 191, 193
human tuberculosis 24, 25
immunological 173–190, 250
rates 32
diagnostic tests 12, 24, 25, 43, 45, 46, 154, 163,
193, 195, 199, 200, 207
cost 241
human tuberculosis 16–17, 18
immunopathogenesis 174
performance 47
sensitivity 162, 241