Bovine tuberculosis

264 Index

Mycobacterium bovis continued
genotyping 67
in goats 63, 80–82, 130
growth 143
human-to-human transmission 21, 23
in humans 16–30, 36–37, 63, 65, 226, 239,
240, 253
intra-species transmission 83
Ireland 62–63
lesions 122–123, 124
life history of infection and transmission 43–48
in lions 98
local immunity 126–128
low to medium-high GNI economies 238–242
macroscopic pathology 123–124
molecular typing 58–79, 61–65, 67
Africa 64
Americas 64
Europe 62–64
Oceania 65
molecular virulence mechanisms 106–121
mortality 19
most recent common ancestor (MRCA) 249
multidrug-resistant strains 24
muscle 21
natural resistance 148–149
New Zealand 99
Northern Ireland 67
occupational risk 21
in Old World camelids 84
Paraguay 65
pasture 47
patient demographics 22
population structure 70
in possums 93–94, 97, 99
in predator species 98
proteins 177–178, 198
in road-kill badgers 67
routes 122, 123
seasons 47
in sheep 80–82, 130
in small ruminants 130
South Africa 64, 99
South America 65, 131
Tanzania 64
transmission 17
Uganda 64
UK 62–63
vaccine 216, 217
virulent strains 145, 146
in white-tailed deer 69, 96–97
in wild animals 131–134
in wild boar 95–96, 97–98
in wildlife 63, 93–105
Zambia 64
Mycobacterium tuberculosis 16, 17, 59, 109, 135
B cells 162

in cattle 209

control 147

diagnosis 199

four-drug treatment 23

gene essentiality 251–252

in goats 81

host response 126

in humans 173, 174, 179, 180

immunological footprint 178–179

in vitro 112

in vivo 112

in mice 146

mutation rate 68, 69

proteins 178

virulent strains 143, 145, 146, 198

Mycobacterium tuberculosis complex (MTBC) 34,

58–59, 61, 67, 81, 82, 106, 122, 226

biomarkers 191–205

in camels 85

genomic analysis 107–109

secretion systems 112

mycomembrane 109

national parks 206

natural killer cells 140, 143

necrosis 129, 194, 195, 196

Nepal, water buffalo 84

net present value (NPV) 228

Netherlands 60

neutrophil extracellular traps (NETs) 143

neutrophils 140, 143–144, 146, 158

New Zealand 232, 233 , 235, 249

Biosecurity Act (1993) 228

brushtail possums 97, 98

dairy herds 34

deer 96, 99, 101

eradication 62, 65

feral pigs 83–84, 95

ferrets 217

government funding 236

meat 20

Mycobacterium bovis 99

pigs 83

possums 93–94, 98, 234, 236

vaccination 208

wild pigs 232

Nigeria 64, 84, 240

abattoir workers 22

Fuku elegusi 21

livestock traders 21

nitric oxide 148

non-conventional T cells 158–161

non-human primates 129

HIV 155

non-pulmonary tuberculosis 24

Northern Ireland 65–67, 68