Discovering insulin’s
role in processing
sugar. Identifying a
marker for glucose
control in the
blood. Creating the
technology that gave
the world synthetic human insulin.City of Hope has one of the most influential
diabetes research programs in the world. There,
scientists have revolutionized our understanding
and treatment of the disease. Their work
continues today with exciting developments in
cell transplantation, gene regulation, immune
tolerance and a new understanding of diabetes
as a complex, multifaceted disease.GROUNDBREAKING RESEARCH
“I don’t think any other research institution in
the country has made as many contributions todiabetes research as we have here at
City of Hope,” said Arthur Riggs, Ph.D., who,
along with Keiichi Itakura, Ph.D., synthesized
the first man-made gene and used it to produce
human insulin, which has become the standard
of care for diabetes worldwide.AN INTEGRATED APPROACH
That history is
part inspiration
and part prelude
for today’s
City of Hope
diabetes
researchers, who
are working on an
integrated approach to the disease. Collaborating
with colleagues around the world, they are
speeding toward a common goal: eradicating
type 1 diabetes.INSIDE THE HUNT
FOR A CURE
For almost 50 years,
City of Hope has
been at the forefront
of breakthroughs in
diabetes research.
Now, scientist
Arthur Riggs, Ph.D.,
and his team feel
a cure is within
their grasp.
To learn more about City of Hope and the Wanek Project for
Type 1 Diabetes, visit CityofHope.org/Diabetes.
(From left to right): Rama Natarajan, Ph.D., National Business Products Industry Professor in Diabetes Research; Defu Zeng, professor, Diabetes & Metabolism Research
Institute; Bart Roep, Ph.D., Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes; Fouad Kandeel, M.D., Ph.D., Arthur D. Riggs Distinguished Chair in Diabetes &
Metabolism Research; Arthur Riggs, Ph.D., Samuel Rahbar Chair in Diabetes & Drug Discovery; Debbie Thurmond, Ph.D., Ruth B. & Robert K. Lanman Chair in Gene
Regulation & Drug Discovery Research