Letter reSeArCH
Extended Data Fig. 10 | Schematic summary. Top, scheme of the
postulated origin of resident synovial CX 3 CR1+ lining macrophages that
constantly repopulate from proliferating tissue resident CX 3 CR1−MHCII+
interstitial macrophages. Bottom, tight-junction-forming resident
lining macrophages form a protective barrier for joint structures that
disintegrates during arthritis, enabling infiltration of inflammatory
myeloid cells.