The Analytical Scientist - 07.2019

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Drug testing for precision medicine

The final stage of precision medicine is to tailor the treatment to the patient’s own genetic and epigenetic makeup.

Here, individual 3D spheroids were used to assess the impact of different drugs. 3D spheroids grown from two

cell lines are visualized using imaging mass cytometry. The colors indicate the presence of three antibody markers;

red for E-Cadherin, blue for pS6, and green for pERK. This multidimensional perturbation data reveals detailed

mechanistic insight into the complex responses of the microtissues to the drugs.

Credit: Vito Zanotelli

Reference

1. N Damond et al., “A map of human type 1 diabetes progression by imaging mass cytometry”, Cell Metab, 29, 755–768 (2019). DOI: 10.1016/j.cmet.2018.11.014.

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