Letter reSeArCH
from the National Heart, Lung, and Blood Institute (1T32HL120824 to B.W.Z.).
The contents of this manuscript are solely the responsibility of the authors.
Author contributions A.A.B. wrote the manuscript. A.A.B. and I.L.W. conceived
and designed all experiments. A.A.B., R.E.B. and M.M. performed all flow
cytometry analyses, generated human macrophages, and performed in vitro
phagocytosis assays. A.A.B., R.E.B. and M.M. performed in vivo experiments
and S.A.B. assisted with in vivo phagocytosis measurements. B.W.Z. assisted
with the design of neuraminidase experiments. M.K. performed single-cell RNA-
sequencing analysis. J.H. assisted with live-cell microscopy. L.J.B. assisted with
statistical analysis and manuscript preparation. O.D. and V.K. provided primary
human ovarian cancer samples. I.L.W. supervised the research and edited the
manuscript.
Competing interests A.A.B. and I.L.W. are co-inventors on a patent application
(62/684,407) related to this work. I.L.W. is a founder, director, stockholder and
consultant of Forty Seven, a cancer immunotherapy company.Additional information
supplementary information is available for this paper at https://doi.org/
10.1038/s41586-019-1456-0.
Correspondence and requests for materials should be addressed to I.L.W.
Peer review information Nature thanks Gregory Beatty, Heinz Läubli and the
other, anonymous, reviewer(s) for their contribution to the peer review of this
work.
Reprints and permissions information is available at http://www.nature.com/
reprints.