Extended Data Fig. 10 | VDR signalling controls gut inf lammation. a–c, Daily
weight loss (a) of Vdr+/+ and Vdr−/− mice during the course of DSS-induced colitis.
Clinical scores (b) and haematoxylin and eosin histology (c) of representative
colons on day 10 of colitis are shown. d, Schematic representation of the T cell-
adaptive transfer model of colitis. Either Vdr+/+ or Vdr−/− naive T cells are
transferred to Rag1−/− mice. e–g, Weight loss (e) of Rag1−/− mice in d during the
course of T cell-adaptive transfer-induced colitis. Clinical scores (f) and
haematoxylin and eosin histology (g) of representative colons on day 67 of
colitis are shown. Data are representative of two independent experiments.
n represents biologically independent animals. Data are mean ± s.e.m. in a, b, e
and f. *P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA followed by the
Bonferroni post hoc test (a and e) or two-tailed Student’s t-test (b and f).