704 7 FEBRUARY 2020 • VOL 367 ISSUE 6478 sciencemag.org/custom-publishing SCIENCEnew products: cell/tissue culture
LIFE SCIENCE TECHNOLOGIES Produced by the Science/AAAS Custom Publishing Office
Perfusion-Based Dendritic Cell
Culture Platform
The Corning MicroDEN automated
perfusion system enables the efficient
generation of dendritic cells from
monocytes. It delivers reproducible
results in less time while reducing
contamination risk, as compared to
the current “Gold Standard” manual
approach to manufacturing dendritic
cells. The system is programmed
to perform the generation, washing, and harvesting steps with
Corning single-use, closed-system technology. The technician
loads peripheral blood mononuclear cells (PBMCs) or enriched
monocytes with the preferred differentiation media, and places the
MicroDEN system into the incubator.
Corning
F o r i n f o: 8 0 0 - 492-1110
http://www.corning.com/lifesciencesNewly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this
space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not
implied. Additional information may be obtained from the manufacturer or supplier.Electronically submit your new product description or product literature information! Go to http://www.sciencemag.org/about/new-products-section for more information.Cell Line for Recombinant Antibody Production
ProteoGenix decided to overcome the cost and timeline issues
associated with the production of monoclonal antibodies for
preclinical trials. Our solution? XtenCHO, a high-performance cell
line combining high-productivity yields with inexpensive reagents.
As proven in our comparative study, this new Chinese hamster ovary
(CHO) transient gene expression system outperforms most of the
solutions currently available. For pembrolizumab, utolimumab, and
claudiximab production, XtenCHO’s production yields are 1.2–1.9
times higher than ExpiCHO and 3.0–8.5 times higher than CHO-S
(with each system measured in their optimal conditions). In ideal
conditions, XtenCHO achieves a maximum yield of 1.28 g/L for
claudiximab. Its high efficiency was also validated for chimeric
(0.5 g/L) and bispecific antibodies (CrossMab, DuoBody, and Fab-Fab;
yields around 200 mg/L). At ProteoGenix we strive for the success
of every antibody production project. XtenCHO is our solution for
decreasing the production costs of therapeutic antibodies and
accelerating your way to the clinic.
ProteoGenix
For info: +33-(0)-390-20-54-70
http://www.proteogenix.scienceIncubation Monitoring System
The OLYMPUS Provi CM20 monitoring system provides quantitative
data about the health of cell cultures while they are in the incubator.
The system periodically scans the cultures, counts the number of
cells without the need of staining or peeling, determines confluency,
and wirelessly communicates the data to a tablet or PC. It has a
thin, compact design, and can be installed in confined spaces.
Using the CM20 system, you can acquire data that will improve the
reproducibility and stability of your cell culture process. Cultivating
cell cultures can be costly, complicated, and time consuming, since it
involves multiple steps and careful timing; the CM20 improves quality
management and reduces the amount of labor involved. With proven
experience in regenerative medicine and expertise in optics, imageanalysis, and data management, Olympus is uniquely positioned to
empower users to push the boundaries of regenerative medicine.
Olympus
For info: 609-820-5176
http://www.olympus-lifescience.com/en/cell_culture_solution/cm2018-Well Slides
With its thin ibidi Polymer Coverslip Bottom, the μ-Slide 18 Well
allows for excellent cell adhesion onto the tissue culture–treated
surface. In addition, it has the highest optical quality and is ideally
suited for a variety of microscopic techniques, such as widefield
fluorescence, confocal microscopy, and differential interference
contrast. For scientists who perform special microscopic
applications, such as total internal reflection fluorescence and
superresolution microscopy, ibidi provides the μ-Slide 18 Well
Glass Bottom with a #1.5H D 263 M Schott glass. It is also available
as a sticky-Slide 18 Well without any bottom, which enables the
researcher to mount any chosen substrate. The entire μ-Slide 18
Well family is ideal for experiments with small cell numbers and
low reagent volumes. The spaces between the individual well walls
minimize any well-to-well crosstalk and contamination. Scientists
who would like to test one of the μ-Slide 18 Well variations with their
own experiments can request free samples at ibidi.com.
ibidi
For info: 844-276-636 3
ibidi.comAutomated Cell Culture Analyzer
BioProfile FLEX2 combines Nova’s groundbreaking MicroSensor
Card technology with optical measurement and freezing point
osmometry for an automated, comprehensive cell culture analyzer
that eliminates chemistry sensor maintenance, increases analyzer
speed, and reduces sample volume. The full 16-cell-culture test
menu includes glucose, lactate, glutamine, glutamate, ammonium,
sodium, potassium, calcium, pH, PCO 2 , PO 2 , total cell density, viable
cell density, viability, cell diameter, and osmolality. Compared to the
previous generation BioProfile FLEX, there is no maintenance for any
of the 11 chemistry and gas sensors, sample volume for the full test
menu is reduced by 75% to 275 μL, and testing time is reduced to
just 4.5 min. Automated sampling from 96-well plates, syringes, or a
24-position external “load-and-go” sample tray provides maximum
workflow flexibility and efficiency for cell culture monitoring.
Nova Biomedical
For info: 781-894-0800
http://www.novabio.us/flex-2/index.phpInductive Charging Stand
An inductive charging stand is now available for the BRAND
HandyStep touch and HandyStep touch S repeating pipettes. The
stand allows for easy charging of the instrument without a plug
connection. A blue light indicates when the instrument is charging
and goes out when charging is completed. A tip can be inserted,
and the instrument can be used simultaneously while charging. The
stand is available separately or in an attractively priced bundle with
either pipette.
BrandTech Scientific
For info: 888-522-2726
http://www.brandtech.com