Science_-_6_March_2020

new products

SCIENCE sciencemag.org/custom-publishing 6 MARCH 2020 • VOL 367 ISSUE 6482 1157

Produced by the Science/AAAS Custom Publishing Office LIFE SCIENCE TECHNOLOGIES

Flow Reactor for Kilogram-Scale Production

The FlowSyn Maxi from Uniqsis is a high-

throughput flow reactor for process chemists

looking to optimize reaction conditions before

scaling-up synthetic production to multiple

kilograms per day. It combines the benefits

of Uniqsis’ proven FlowSyn technology with

high flow rates (up to 100 mL/min) in a compact, benchtop design.

The highly intuitive user interface quickly guides you through the

process for setting up a flow chemistry reaction. Once set up, the

reactor automatically runs the experiment unattended, ensuring

that critical parameters remain within defined limits. Robustly

constructed from epoxy-coated and bead-blasted stainless steel,

it can be specified with stainless steel, Hastelloy, or polytetra-

fluoroethylene (PTFE) flow paths. The unit is fitted with larger-bore

inlet tubing and upgraded inlet/outlet solenoid valves with bigger

fluidic channels to cope with the increased flow rate. The FlowSyn

Maxi is designed to carry out superheated reactions up to +260°C

(1,400 psi) and cooled reactions down to –70°C—making it one of

the most versatile process-scale flow reactors available.

Uniqsis

For info: +44-(0)-845-864-7747

http://www.uniqsis.com/paproductsdetail.aspx?id=flw_maxi

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this

space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not

implied. Additional information may be obtained from the manufacturer or supplier.

Electronically submit your new product description or product literature information! Go to http://www.sciencemag.org/about/new-products-section for more information.

and offer high purity and low endotoxin levels ideal for in vivo ap-

plications. The antibodies are targeted against key immune system

proteins, including clinically relevant checkpoint proteins such as

PD-1, CTLA-4, and OX40.

Absolute Antibody

For info: 617-377-4057

absoluteantibody.com

Heparanase and Hyaluronidase Activity Kits

AMS Biotechnology supplies Razie assay kits to measure enzyme ac-

tivity of heparanase and hyaluronidase in cell culture supernatants,

human plasma, biological fluids, and tissue samples. Our kits have

been used for research into anti-inflammatory responses, kidney

disease, cancer research, and intervertebral disc degeneration. Hep-

aranase and hyaluronidase enzymes play an important role in the

extracellular matrix. Our kits provide a solution to the performance

and standardization problems found with traditional measurement

techniques used for these types of enzymes. Each assay is available

in two formats: (1) with enzyme as positive control to demonstrate

digestion/activity, and (2) without positive control, for end-users who

have their own enzyme for use as positive control.

AMS Biotechnology

For info: 800-987-0985

http://www.amsbio.com

Antigen and Antibody Conjugation Kits

The Native Antigen Company offers a selection of complementary,

easy-to-use antibody conjugation kits, with a wide range of labels

suitable for use in most applications. On request we can also under-

take custom conjugation of proteins and antibodies. The kits utilize

a novel chemistry to generate highly reproducible antigen and anti-

body conjugates with a range of different labels, including enzymes,

fluorochromes, and biotin. No reconstitution is required, and these

kits can be used to generate liquid stable conjugates, which are fully

scalable from 0.01 mg to gram scale. Incorporation is highly efficient,

helping to ensure lot-to-lot consistency, low backgrounds, and im-

proved assay sensitivity.

The Native Antigen Company

For info: +44-(0)-1865-595230

thenativeantigencompany.com/conjugation-kits

pQA Portable Quadrupole Analyzer

The Hiden pQA portable gas analyzer is a versatile mass spectrom-

eter and offered with a range of interchangeable sampling inlets to

suit a broad application range. Membrane introduction mass spec-

trometry (MIMS) inlets are offered for analysis of dissolved species

in ground water, fermentation cultures, soil samples, and general

applications where analysis of dissolved species in a liquid sample

is required. The system is suited to gas analysis applications, where

sample volume is small, and for environmental applications where

detection of low concentration levels is required. The pQA system

has a mass range of 200 atomic mass units (amu) and sub-ppb

detection levels; extended mass range to 300 amu is optional. The

system is supplied in a Pelican case and can be powered by a 12-V

supply for field use, battery and/or solar powered, or a 220-V supply

for laboratory use.

Hiden Analytical

For info: +44-(0)-1925-445225

http://www.hidenanalytical.com

Knockout Cell Lines

CRISPR-Cas9 knockout cell lines from Abcam provide you with reli-

able, off-the-shelf, single-gene knockouts, so that you can confidently

interrogate the relationship between genotype and phenotype

without spending months establishing your own knockout cell line.

We provide a large and expanding range of knockouts in immortal-

ized mammalian cell lines, such as HeLa and HEK293T. All knockout

cell lines are Sanger sequenced, and many have additional Western

blot data to confirm knockout at the proteomic level. With our large

range of ready-made knockouts in commonly used cell lines, and

our ever-expanding range of new targets and cell lines, obtaining

your knockout cell line of choice is as easy as buying a reagent. Don’t

see the cell line you need in our catalog? Register your interest for

your desired knockout cell line and we will be in touch if it’s in our

pipeline.

Abcam

For info: 888-772-2226

http://www.abcam.com

Recombinant Antibodies for In Vivo Research

Absolute Antibody offers VivopureX recombinant mouse antibod-

ies for in vivo research in mouse models. The collection consists

of popular antibody clones, many originally obtained from rats or

hamsters, which Absolute Antibody has engineered into mouse

anti-mouse recombinant versions to improve research results. The

antibodies are available in discounted bulk sizes ranging from

1 mg to 100 mg. VivopureX antibodies are species-matched chimeric

antibodies, consisting of a clone’s original antigen-binding variable

domain with a mouse-constant domain, which means they do not

induce neutralizing antibodies in mouse models. In addition, the

antibodies feature engineered effector functions, with fragment

crystallizable (Fc) receptor binding tailored to best suit popular ap-

plications such as depletion, agonism, or blocking. All antibodies are

produced recombinantly for ensured batch-to-batch reproducibility