(R.A.-S., K.P.-J.), and Li Ka Shing foundation (D.C.W.). J.D.
acknowledges funding from the Alpe d’HuZes foundation/KWF
Dutch Cancer Society Bas Mulder Award (#10218) and the
Oncode Institute.Author contributions:S.B. conceived of the
experiment. T.H.H.C., T.D.T., and S.B. analyzed data. Statistical
expertise was provided by M.D.Y., D.C.W., and I.Ma. M.D.Y.,
T.J.M., G.C., P.S.T., P.J.C., M.R.S., I.Ma., and K.P.-J. contributed
to discussion. L.M. and M.G.B.T. performed laser capture
microscopy experiments. Samples were curated and/or
experiments were performed by R.A.-S., C.T., S.T., M.O., Y.H.,
M.B., B.C.R., G.B., J.A., M.J., G.A.A.B., J.V., J.C.N., N.S., K.S.-P.,
G.D.S., K.S., T.C., I.Mu., J.D., and K.P.-J. Pathological expertise
was provided by L.H., T.R.W.O., D.R., A.Y.W., N.C., and N.S.
A.C. created kidney illustrations. T.H.H.C., T.D.T., and S.B. wrote
the manuscript. S.B. directed the study.Competing interests:
G.D.S. is a paid consultant for Pfizer, Merck, EUSA Pharma,
and Cambridge Medical Robotics. All other authors declare no
competing interests.Data and materials availability:Raw
sequencing data have been deposited in the European Genome-
phenome Archive (EGA) under study ID EGAD00001004774.
The bespoke code used for the analyses is available on GitHub
(https://github.com/TimCoorens/ClonalNephrogenesis).SUPPLEMENTARY MATERIALS
science.sciencemag.org/content/366/6470/1247/suppl/DC1
Materials and Methods
Figs. S1 to S12
Tables S1 to S8
References ( 13 – 30 )
View/request a protocol for this paper fromBio-protocol.
25 February 2019; resubmitted 4 July 2019
Accepted 6 November 2019
10.1126/science.aax1323Coorenset al.,Science 366 , 1247–1251 (2019) 6 December 2019 5of5
RESEARCH | REPORT
on December 12, 2019^http://science.sciencemag.org/Downloaded from