Nature - USA (2020-06-25)

3

nature research | reporting summary

October 2018

Laboratory animals Animal Care and Use Committee (Protocol# S99116). Transgenic mice including B6.Cg-Tg(Gfap-cre)77.6Mvs/2J,

B6.SJLSlc6a3tm1.1(cre)Bkmn/J, B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J, and B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J were

purchased from The Jackson Laboratory. Both male and female mice were used in this study. All mice at age of postnatal day

30~40 were used. 1year old B6.Cg-Tg(Gfap-cre)77.6Mvs/2J mice were also used to perform surgery to induce lesion.

Wild animals This study did not involve wild animals.

Field-collected samples This study did not involve samples collected from the field.

Ethics oversight All procedures were conducted in accordance with the guide of The University of California San Diego Institutional Animal Care

and Use Committee.

Note that full information on the approval of the study protocol must also be provided in the manuscript.