Nature - USA (2020-01-02)

n=11

2

3

3

3

3

11

12

11 11 7

4

7

4

4

4

4

3

4

4

4

Leukocytes

in PBMCs

NK

pDC

mDC

B

Mono

T

AE

AE/ID

IV

ID

low

ID

high

P 2 4 8 12 16 20 24

AE

AE/ID

IV

ID

low

ID

high

P 2 4 8 12 16 20 24

Weeks after BCG immunization

P 2 4 24

AE

IV

ID

high

ID

low

Weeks after BCG

NK

Neut

pDC

mDC

B

MΦ

T

Leukocytes in BAL

T cells in BAL

CD4

CD8

MAIT

iNKT

Vγ 9 +

T cells

in PBMCs

CD4

CD8

V 9 +

MAIT

iNKT

V 9 –

P 2 4 24

AE

IV

ID

high

ID

low

Weeks after BCG

Weeks after BCG immunization

a

b

c d

0.047

0.012

<0.001 <0.001 <0.001 <0.001 <0.001 0.003 <0.001

0.003 <0.001 0.029

0.032 <0.001 0.016 0.020 0.036

0.039

0.015

0.002 0.009 0.003 <0.001 0.021

Extended Data Fig. 3 | See next page for caption.