Nature - USA (2020-01-02)

a

b

Total IL-17 (%)

Pie colors

IFN

IL-2

TNF

IFN

IL-2

TNF

CD154

IFN

IL-2

TNF

IFN

IL-2

TNF

CD4 Response (PBMCs)

CD8 Response (PBMCs)

CD4 Response (BAL)

CD8 Response (BAL)

Cytokine-producing

T cells in PBMCs (%)

Cytokine-producing

T cells in BA

L (%)

IL-17 positive (total)

IL-17 single-positive

Pie colors

Pie colors

Pie colors

2.0

3.0

1.0

0.0

0.0

0.4

0.8

0

10

20

30

0

4.0

8.0

12.0

0.0

0.4

0.8

0

4

8

0.0

0.1

0.2

To tal IL-17 (%)

To tal IL-17 (%)

IDlow IDhigh IV AE AE/ID

IDlow IDhigh IV AE AE/ID

IDlow IDhigh IV AE AE/ID

IDhigh IV

IL-17 positive (total)

IL-17 single-positive

Bars

AE

AE/ID

IV

IDlow

IDhigh

CD154 single-positive

Extended Data Fig. 5 | See next page for caption.