Nature - USA (2020-01-02)

a

b

c

d

BCG Regimen

048 12 048 12 04812 048 12 048 12

0

1

2

4

8

0.0

0.5

1.0

1.5

2

0.0

0.5

1.0

1.5

4

8

048 12

tntc

400

300

200

100

10

0

tntc

400

300

200

100

10

0

0 4 6 812 0 4 6 812 0 4 6 812 0 4 6 8120 4 6 812 0 4 6 812

0

1

2

3

4

8

Weeks after Mtb challenge

Weeks after Mtb challenge

048 12 048 12 048 12 04812 048 12 048 12

IFN

spot-forming units (per 200,000 cells)

Cytokine-producing CD4

T cells (%)

Cytokine-producing CD8

T cells (%)

ESAT-6 (Mtb only)

CFP-10 (Mtb only)

PPD (BCG/Mtb)

ES

AT

-6/CFP-10

PPD (BCG/Mtb)

ES

AT

-6/CFP-10

log

10

(endpoint titer)

IgG

IgA

IgM

0 4 12

2

3

4

5

6

1

2

3

4

5

1

2

3

4

5

Unvax IDlow IDhigh IV AE AE/ID

Unvax IDlow IDhigh IV AE AE/ID

Weeks after Mtb

0.00 2

0.00 4

0.00 2

0.00 6

0.00 2

0.00 4

0.004

0.004 0.016 0.695 0.004 0.006

0.002 0.008 0.160 0.004 0.002

0.004 0.008 0.625 0.00 20 .002

0.004 0.039 0.031 0.014 0.006

IDhigh

IV

AE

IDlow

AE/ID

Unvax

log

10

(endpoint titer)

log

10

(midpoint titer)

Extended Data Fig. 9 | See next page for caption.