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Extended Data Fig. 4 | Kinetic analysis of the interaction of the chaperones
with α-synuclein variants. a–c, Kinetic analysis by bio-layer interferometry of
biotinylated Skp (a), SecB (b) and HSC70ADP (c) to different α-synuclein variants
(α-synuclein (top), acetyl-α-synuclein (middle) and ∆N-α-synuclein (bottom).
Black lines represent least-square fits to the data. The residuals of the fits are
shown below each set of bio-layer interferometry curves. Each individual
kinetic experiment was run twice in triplicates with similar results.