Extended Data Fig. 10 | Mechanism of chaperone-controlled regulation of
α-synuclein function, conformation and localization in mammalian cells.
Cellular chaperones (yellow) interact with the N-terminal segment of
α-synuclein (red), thus actively regulating its functional species by shifting
conformational equilibria. Impairment of the natural α-synuclein–chaperone
ratio or abrogation of the α-synuclein–chaperone interaction by post-
translational modifications can lead to the formation of pathological species,
including the accumulation of α-synuclein at mitochondria.