EVERYTHING
WORTH
KNOWING
68 DISCOVERMAGAZINE.COM
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ADHD, OR ATTENTION
DEFICIT HYPERACTIVITY
DISORDER, usually conjures
images of a child bouncing
off the walls, or an adult
who’s constantly distracted.
Symptoms like these are
what first caught physician
Sir Alexander Crichton’s
attention. In his 1798 book
on mental conditions, he
wrote that people who expe-
rienced such symptoms “say
they have the fidgets.”
Eventually, experts would
realize ADHD is much more
than that. At various times
throughout history, experts
believed there was scant
evidence of abnormal activ-
ity in the brain, and instead
considered it a moral defect
or a hyperkinetic reaction
of childhood. It wasn’t until
the 1930s and ’40s that
researchers realized there
was a strong link between
ADHD-like symptoms and
the brain.
Now, although many
mysteries still shroud this
disorder, we know the brain
and how it functions is a cru-
cial factor, and the scope of
symptoms goes well beyond
fidgeting.
When the brain
gets in the way.
BY LACY SCHLEY
ADHD
What’s Going on
in the Brain
Kids and adolescents with
ADHD tend to have about
3 to 4 percent less brain volume
than their neurotypical peers.
Plus, the brain’s outer layer, or
cortex, usually develops more
slowly, lagging behind by about
three years. Even in adulthood,
some regions don’t catch up.
These reductions could explain
some classic ADHD symptoms,
such as difficulty focusing or
fidgeting.
Although these aren’t all the
areas and networks implicated
in the disorder, here are some
key players and how they differ
in ADHD brains.
Prefrontal cortex: Part of
the frontal lobe; seat of
complex decision making,
strategic planning and
working memory (when
you’re holding information
that’s relevant to the task
at hand, like remembering
you already added sugar
while making a cake).
In ADHD brains: Tends
to be thinner in kids,
adolescents and some
adults.
Basal ganglia: Involved mainly
in motor control, some reward-
related emotions and behaviors,
attention and time estimation.
In ADHD brains: Tends to be
smaller, and less active in kids
specifically.
Brain Structures
and Regions
Frontal lobe: Made up
of many substructures;
hub of emotions and
personality; carries out
executive functions like
planning, control and
decision making.
In ADHD brains: Tends
to be less active and
smaller.
Ventral
anterior
cingulate
cortex
Dorsal
anterior
cingulate
cortex
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