Nature - USA (2020-10-15)

4

nature research | reporting summary

April 2020

Animals and other organisms

Policy information about studies involving animals; ARRIVE guidelines recommended for reporting animal research

Laboratory animals Mus musculus, iPKR knockin mice, Col1a1.TRE-GFP.shmir-eIF4E knockin mice, Floxed TRAP mice, Floxed tdTomato reporter mice,

Som-Cre mice, PKCδ -Cre mice and C57Bl/6J mice from Jackson labs. Male and Female, 3-6 months old.

Wild animals The study did not involve wild animals.

Field-collected samples The study did not involve samples collected from the field.

Ethics oversight New York University University Animal Welfare Committee and Institutional Biosafety Committee approved and provided guidance

on the study protocol.

Note that full information on the approval of the study protocol must also be provided in the manuscript.