▶Rifampicinis predicted to decrease the exposure tosorafenib.
oTheoretical
▶Rifampicinmarkedly decreases the exposure tostatins
(atorvastatin).Atorvastatinshould be taken at the same time
asrifampicin,p. 132, p. 364.oStudy
▶Rifampicinmoderately decreases the exposure tostatins
(fluvastatin). Monitor and adjust dose.oStudy
▶Rifampicinvery markedly decreases the exposure tostatins
(simvastatin).oStudy
▶Rifampicinis predicted to decrease the exposure to
sulfonylureas.oStudy
▶Rifampicinis predicted to decrease the exposure tosunitinib.
Avoid or adjustsunitinibdose.oStudy
▶Rifampicindecreases the concentration oftacrolimus. Monitor
and adjust dose.rStudy
▶Rifampicinmarkedly decreases the exposure totamoxifen.
qStudy
▶Rifampicinis predicted to decrease the exposure totaxanes
(cabazitaxel, paclitaxel). Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure totaxanes
(docetaxel).rTheoretical
▶Rifampicinis predicted to decrease the concentration of
temsirolimus. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure totenofovir
alafenamide. Avoid.oTheoretical
▶Rifampicindecreases the exposure toterbinafine. Adjust dose.
oStudy
▶Rifampicindecreases the exposure totetracyclines
(doxycycline). Monitor and adjust dose.oStudy
▶Rifampicinis predicted to decrease the exposure to
theophylline. Adjust dose.oStudy
▶Rifampicinis predicted to markedly decrease the exposure to
ticagrelor. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure totivozanib.
rStudy
▶Rifampicinmoderately decreases the exposure totizanidine.
nStudy
▶Rifampicinis predicted to decrease the exposure totofacitinib.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure totolvaptan.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure totoremifene.
Adjust dose.oStudy
▶Rifampicinis predicted to decrease the exposure to
trabectedin. Avoid.rTheoretical
▶Rifampicindecreases the exposure totrimethoprim.o
Study
▶Rifampicindecreases the efficacy ofulipristal. For FSRH
guidance, seeContraceptives, interactionsp. 497.r
Anecdotal
▶Rifampicinis predicted to decrease the exposure to
vandetanib. Avoid.oStudy
▶Rifampicinis predicted to moderately decrease the exposure
tovelpatasvir. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure to
vemurafenib. Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure tovenetoclax.
Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure tovinca
alkaloids(vinblastine, vincristine, vindesine).rTheoretical
▶Rifampicinis predicted to decrease the exposure tovinca
alkaloids(vinflunine). Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure tovinca
alkaloids(vinorelbine). Use with caution or avoid.r
Theoretical
▶Rifampicinis predicted to decrease the exposure to
vismodegib. Avoid.oTheoretical
▶Rifampicinpotentially increases the risk of nephrotoxicity
when given withvolatile halogenated anaesthetics
(methoxyflurane). Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure to
vortioxetine. Monitor and adjust dose.oStudy
▶Rifampicinis predicted to decrease the concentration of
voxilaprevir. Avoid.rStudy
▶Rifampicinmarkedly decreases the exposure tozaleplon.
oStudy
▶Rifampicinmoderately decreases the exposure tozolpidem.
oStudy
▶Rifampicinis predicted to decrease the exposure tozopiclone.
Adjust dose.oStudy
Rifaximin
▶Ciclosporinvery markedly increases the exposure torifaximin.
rStudy
Rilpivirine
▶Antacidsare predicted to decrease the exposure torilpivirine.
Antacidsshould be taken 2 hours before or 4 hours after
rilpivirine,p. 415.rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)markedly decrease the exposure to
rilpivirine. Avoid.rStudy
▶Antiepileptics(oxcarbazepine)are predicted to decrease the
concentration ofrilpivirine. Avoid.rTheoretical
▶Bosentanis predicted to decrease the exposure torilpivirine.
Avoid.rTheoretical
▶Calcium salts(calcium carbonate)are predicted to slightly
decrease the exposure torilpivirine.Calcium carbonateshould
be taken 2 hours before or 4 hours afterrilpivirine.r
Theoretical
▶Efavirenzis predicted to decrease the exposure torilpivirine.
Avoid.rTheoretical
▶Enzalutamidemarkedly decreases the exposure torilpivirine.
Avoid.rStudy
▶Etravirineis predicted to decrease the exposure torilpivirine.
Avoid.rTheoretical
▶H 2 receptor antagonistsare predicted to decrease the exposure
torilpivirine.H 2 receptor antagonistsshould be taken 12 hours
before or 4 hours afterrilpivirine.rStudy
▶Mitotanemarkedly decreases the exposure torilpivirine.
Avoid.rStudy
▶Nevirapineis predicted to decrease the exposure torilpivirine.
Avoid.rTheoretical
▶Proton pump inhibitorsare predicted to decrease the exposure
torilpivirine. Avoid.rStudy
▶Rifabutinslightly decreases the exposure torilpivirine. Adjust
dose.rStudy
▶Rifampicinmarkedly decreases the exposure torilpivirine.
Avoid.rStudy
▶St John’sWortis predicted to decrease the exposure to
rilpivirine. Avoid.rTheoretical
Riluzole
FOOD AND LIFESTYLECharcoal-grilled foods are predicted to
decrease the exposure to riluzole.
▶SSRIs(fluvoxamine)are predicted to increase the exposure to
riluzole.oTheoretical
Riociguat→seeTABLE 8p. 848 (hypotension)
▶Antacidsslightly decrease the exposure toriociguat.Antacids
should be taken 2 hours before or 1 hour afterriociguat.n
Study
▶Antifungals, azoles(itraconazole)are predicted to increase the
exposure toriociguat. Avoid.oStudy
▶Antifungals, azoles(ketoconazole)moderately increase the
exposure toriociguat. Avoid.oStudy
▶Ciclosporinis predicted to increase the exposure toriociguat.
oTheoretical
▶HIV-protease inhibitors(ritonavir)are predicted to increase the
exposure toriociguat. Avoid.oTheoretical
▶Riociguatis predicted to increase the risk of hypotension
when given withphosphodiesterase type-5 inhibitors. Avoid.
rTheoretical→Also seeTABLE 8p. 848
Risedronate→see bisphosphonates
Risperidone→seeTABLE 8p. 848 (hypotension),TABLE 9p. 849 (QT-
interval prolongation),TABLE 11p. 849 (CNS depressant effects)
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
torisperidone. Adjust dose.oStudy→Also seeTABLE 11
p. 849
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the exposure torisperidone. Adjust dose.
oStudy→Also seeTABLE 9p. 849BNFC 2018 – 2019 Rifampicin—Risperidone 985
Interactions|Appendix 1A1