▶Soltel(Kent Pharmaceuticals Ltd)
Salmeterol (as Salmeterol xinafoate) 25 microgram per
1 doseSoltel 25 micrograms/dose inhaler CFC free| 120 doseP
£ 19. 95 DT = £ 29. 26
▶Vertine(Teva UK Ltd)
Salmeterol (as Salmeterol xinafoate) 25 microgram per
1 doseVertine 25 micrograms/dose inhaler CFC free| 120 doseP
£ 23. 40 DT = £ 29. 26
Combinations available:Fluticasone with salmeterol,p. 163BETA 2 -ADRENOCEPTOR AGONISTS,
SELECTIVE›SHORT-ACTING
eiiiiF 154Salbutamol
(Albuterol)
lINDICATIONS AND DOSE
Acute asthma
▶BY INTRAVENOUS INJECTION
▶Child 1–23 months: 5 micrograms/kg for 1 dose, dose to
be administered over 5 minutes, reserve intravenous
beta 2 agonists for those in whom inhaled therapy
cannot be used reliably or there is no current effect
▶Child 2–17 years: 15 micrograms/kg (max. per dose
250 micrograms) for 1 dose, dose to be administered
over 5 minutes, reserve intravenous beta 2 agonists for
those in whom inhaled therapy cannot be used reliably
or there is no current effect
▶BY CONTINUOUS INTRAVENOUS INFUSION
▶Child: 1 – 2 micrograms/kg/minute, adjusted according
to response and heart rate, increased if necessary up to
5 micrograms/kg/minute, doses above
2 micrograms/kg/minute should be given in an
intensive care setting, reserve intravenous beta 2
agonists for those in whom inhaled therapy cannot be
used reliably or there is no current effect
Moderate, severe, or life-threatening acute asthma
▶BY INHALATION OF NEBULISED SOLUTION
▶Child 1 month–4 years: 2. 5 mg, repeat every
20 – 30 minutes or when required, give via oxygen-
driven nebuliser if available
▶Child 5–11 years: 2. 5 – 5 mg, repeat every 20 – 30 minutes
or when required, give via oxygen-driven nebuliser if
available
▶Child 12–17 years: 5 mg, repeat every 20 – 30 minutes or
when required, give via oxygen-driven nebuliser if
available
Moderate and severe acute asthma
▶BY INHALATION OF AEROSOL
▶Child: 2 – 10 puffs, each puff is to be inhaled separately,
repeat every 10 – 20 minutes or when required, give via
large volume spacer (and a close-fitting face mask in
children under 3 years), each puff is equivalent to
100 micrograms
Exacerbation of reversible airways obstruction (including
nocturnal asthma)|Prophylaxis of allergen- or exercise-
induced bronchospasm
▶BY INHALATION OF AEROSOL
▶Child: 100 – 200 micrograms, up to 4 times a day for
persistent symptoms
▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES
▶Child 1 month–1 year: 100 micrograms/kg 3 – 4 times a
day (max. per dose 2 mg), inhalation route preferred
over oral route
▶Child 2–5 years: 1 – 2 mg 3 – 4 times a day, inhalation
route preferred over oral route
▶Child 6–11 years: 2 mg 3 – 4 times a day, inhalation route
preferred over oral route
▶Child 12–17 years: 2 – 4 mg 3 – 4 times a day, inhalation
route preferred over oral routeSevere hyperkalaemia
▶BY INTRAVENOUS INJECTION
▶Neonate: 4 micrograms/kg, repeated if necessary, to be
administered over 5 minutes.▶Child: 4 micrograms/kg, repeated if necessary, to be
administered over 5 minutes
▶BY INHALATION OF NEBULISED SOLUTION
▶Neonate: 2. 5 – 5 mg, repeated if necessary, intravenous
injection route preferred over inhalation of nebulised
solution.▶Child: 2. 5 – 5 mg, repeated if necessary, intravenous
injection route preferred over inhalation of nebulised
solution
Chronic asthma
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 3–11 years: 4 mg twice daily
▶Child 12–17 years: 8 mg twice daily
EASYHALER®SALBUTAMOL
Acute bronchospasm
▶BY INHALATION OF POWDER
▶Child 5–11 years: 100 – 200 micrograms; maximum
800 micrograms per day
▶Child 12–17 years:Initially 100 – 200 micrograms,
increased if necessary to 400 micrograms; maximum
800 micrograms per day
Prophylaxis of allergen- or exercise-induced
bronchospasm
▶BY INHALATION OF POWDER
▶Child 5–11 years: 100 – 200 micrograms
▶Child 12–17 years: 200 microgramsPULVINAL®SALBUTAMOL
Acute bronchospasm
▶BY INHALATION OF POWDER
▶Child 5–17 years:Initially 200 micrograms, up to
800 micrograms daily for persistent symptoms
Prophylaxis of allergen- or exercise-induced
bronchospasm
▶BY INHALATION OF POWDER
▶Child 5–17 years: 200 micrograms
SALBULIN NOVOLIZER®
Acute bronchospasm
▶BY INHALATION OF POWDER
▶Child 6–11 years: 100 – 200 micrograms, up to
400 micrograms daily for persistent symptoms
▶Child 12–17 years:Initially 100 – 200 micrograms, up to
800 micrograms daily for persistent symptoms
Prophylaxis of allergen- or exercise-induced
bronchospasm
▶BY INHALATION OF POWDER
▶Child 6–11 years: 100 – 200 micrograms
▶Child 12–17 years: 200 micrograms
VENTOLIN ACCUHALER®
Acute bronchospasm
▶BY INHALATION OF POWDER
▶Child 5–17 years:Initially 200 micrograms, up to 4 times
daily for persistent symptoms
Prophylaxis of allergen- or exercise-induced
bronchospasm
▶BY INHALATION OF POWDER
▶Child 5–17 years: 200 micrograms
PHARMACOKINETICS
▶At recommended inhaled doses, the duration of action
of salbutamol is about 3 to 5 hours.lUNLICENSED USENot licensed for use in hyperkalaemia.
▶With oral useSyrup and tablets not licensed for use in
children under 2 years.156 Airways disease, obstructive BNFC 2018 – 2019
Respiratory system3