and may affect performance of skilled tasks (e.g. cycling or
driving); alcohol should be avoided.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral solution
▶Xyzal(UCB Pharma Ltd)
Levocetirizine dihydrochloride 500 microgram per 1 mlXyzal
0. 5 mg/ml oral solution sugar-free| 200 mlP£ 6. 00 DT = £ 6. 00
Tablet
▶Levocetirizine hydrochloride (Non-proprietary)
Levocetirizine dihydrochloride 5 mgLevocetirizine 5 mg tablets|
30 tabletP£ 4. 45 DT = £ 4. 37
▶Xyzal(UCB Pharma Ltd)
Levocetirizine dihydrochloride 5 mgXyzal 5 mg tablets|
30 tabletP£ 4. 39 DT = £ 4. 37Loratadine 22-May-2017
lINDICATIONS AND DOSE
Symptomatic relief of allergy such as hay fever, chronic
idiopathic urticaria
▶BY MOUTH
▶Child 2–11 years (body-weight up to 31 kg): 5 mg once daily
▶Child 2–11 years (body-weight 31 kg and above): 10 mg
once daily
▶Child 12–17 years: 10 mg once dailylINTERACTIONS→Appendix 1 : antihistamines, non-
sedating
lSIDE-EFFECTS
▶Common or very commonDrowsiness.nervousness
▶UncommonAppetite increased.headache.insomnia
▶Rare or very rareAlopecia.angioedema.dizziness.dry
mouth.fatigue.gastritis.hepatic function abnormal.
nausea.palpitations.rash.seizure.tachycardia
SIDE-EFFECTS, FURTHER INFORMATIONNon-sedating
antihistamines such as loratadine cause less sedation and
psychomotor impairment than the older antihistamines,
but can still occur; sedation is generally minimal. This is
because non-sedating antihistamines penetrate the blood
brain barrier to a much lesser extent.
lPREGNANCYMost manufacturers of antihistamines advise
avoiding their use during pregnancy; however, there is no
evidence of teratogenicity.
lBREAST FEEDINGMost antihistamines are present in
breast milk in varying amounts; although not known to be
harmful, most manufacturers advise avoiding their use in
mothers who are breast-feeding.
lHEPATIC IMPAIRMENT
Dose adjustmentsReduce dose frequency to alternate days
in severe impairment.
lPATIENT AND CARER ADVICE
Driving and skilled tasksAlthough drowsiness is rare,
nevertheless patients and their carers should be advised
that it can occur and may affect performance of skilled
tasks (e.g. cycling or driving); alcohol should be avoided.
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Loratadine 10 mg tablets may be prescribed.
Loratadine syrup 5 mg/ 5 mL may be prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral solution
EXCIPIENTS:May contain Propylene glycol
▶Loratadine (Non-proprietary)
Loratadine 1 mg per 1 mlLoratadine 5 mg/ 5 ml oral solution|
100 mlP£ 2. 24 DT = £ 1. 33Tablet
▶Loratadine (Non-proprietary)
Loratadine 10 mgLoratadine 10 mg tablets| 30 tabletp£ 1. 44
DT = £ 0. 45
▶Clarityn (Loratadine)(Bayer Plc)
Loratadine 10 mgClarityn Allergy 10 mg tablets| 60 tabletp
£ 8. 85
Oral lyophilisate
▶Clarityn (Loratadine)(Bayer Plc)
Loratadine 10 mgClarityn Rapide Allergy 10 mg tablets sugar-free|
10 tabletG£ 3. 24 DT = £ 3. 24Mizolastine 22-May-2017
lINDICATIONS AND DOSE
Symptomatic relief of allergy such as hay fever, urticaria
▶BY MOUTH
▶Child 12–17 years: 10 mg once dailylCONTRA-INDICATIONSCardiac disease.hypokalaemia.
susceptibility to QT-interval prolongation
lINTERACTIONS→Appendix 1 : antihistamines, non-
sedating
lSIDE-EFFECTS
▶Common or very commonAppetite increased.asthenia.
diarrhoea.dizziness.drowsiness.dry mouth.
gastrointestinal discomfort.headache.nausea.weight
increased
▶UncommonAnxiety.arrhythmias.arthralgia.depression.
myalgia.palpitations
▶Rare or very rareHypersensitivity
▶Frequency not knownAsthma exacerbated.bronchospasm
.QT interval prolongation
SIDE-EFFECTS, FURTHER INFORMATIONNon-sedating
antihistamines such as mizolastine cause less sedation and
psychomotor impairment than the older antihistamines,
but can still occur; sedation is generally minimal. This is
because non-sedating antihistamines penetrate the blood
brain barrier to a much lesser extent.
lPREGNANCYMost manufacturers of antihistamines advise
avoiding their use during pregnancy; however, there is no
evidence of teratogenicity.
lBREAST FEEDINGMost antihistamines are present in
breast milk in varying amounts; although not known to be
harmful, most manufacturers advise avoiding their use in
mothers who are breast-feeding.
lHEPATIC IMPAIRMENTManufacturer advises avoid in
significant impairment.
lPATIENT AND CARER ADVICE
Driving and skilled tasksAlthough drowsiness is rare,
nevertheless patients and their carers should be advised
that it can occur and may affect performance of skilled
tasks (e.g. cycling or driving); alcohol should be avoided.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Modified-release tablet
CAUTIONARY AND ADVISORY LABELS 25
▶Mizollen(Sanofi)
Mizolastine 10 mgMizollen 10 mg modified-release tablets|
30 tabletP£ 6. 92 DT = £ 6. 92176 Allergic conditions BNFC 2018 – 2019
Respiratory system3