▶Child 12–17 years:Initially 5 mg every 4 – 6 hours, dose to
be increased if necessary according to severity of pain
▶BY MOUTH USING MODIFIED-RELEASE MEDICINES
▶Child 8–11 years:Initially 5 mg every 12 hours, dose to
be increased if necessary according to severity of pain,
use 12 -hourly modified-release preparations for this
dose; seePrescribing and dispensing information
▶Child 12–17 years:Initially 10 mg every 12 hours, dose to
be increased if necessary according to severity of pain,
use 12 -hourly modified-release preparations for this
dose; seePrescribing and dispensing information
DOSE EQUIVALENCE AND CONVERSION
▶ 2 mg oral oxycodone is approximately equivalent to
1 mg parenteral oxycodone.
ONEXILA XL®
Severe pain
▶BY MOUTH
▶Child 12–17 years:Initially 10 mg every 24 hours, dose to
be increased if necessary according to severity of pain,
some patients may require higher doses than the
maximum daily dose; maximum 400 mg per daylUNLICENSED USEOral solution,Oxynorm®,Longtec®, and
Oxycontin®not licensed for use in children. Capsules and
Dolcodon®PRnot licensed for use in children under
12 years.
IMPORTANT SAFETY INFORMATION
Do not confuse modified-release 12 -hourly preparations
with 24 -hourly preparations, seePrescribing and
dispensing information.lCONTRA-INDICATIONSAcute abdomen.chronic
constipation.cor pulmonale.delayed gastric emptying
lCAUTIONSPancreatitis.toxic psychosis
lINTERACTIONS→Appendix 1 : opioids
lSIDE-EFFECTS
▶Common or very commonAnxiety.appetite decreased.
asthenia.bronchospasm.cognitive impairment.
depression.diarrhoea.dyspnoea.gastrointestinal
discomfort.hiccups.insomnia.lethargy.mood altered.
movement disorders.perception altered.psychiatric
disorders.skin reactions.tremor.urinary frequency
increased
▶UncommonBiliary colic.burping.chest pain.cough.
chills.dehydration.dysphagia.gastrointestinal disorders
.hyperacusia.increased risk of infection.injury.
lacrimation disorder.malaise.memory loss.migraine.
neuromuscular dysfunction.oedema.oral disorders.pain
.seizure.sensation abnormal.sexual dysfunction.SIADH
.speech disorder.supraventricular tachycardia.syncope.
taste altered.thirst.vasodilation.voice alteration
▶Rare or very rareHaemorrhage.lymphadenopathy.
muscle spasms.postural hypotension.photosensitivity
reaction.weight changes
▶Frequency not knownAggression.amenorrhoea.
cholestasis
lBREAST FEEDINGPresent in milk—avoid.
lHEPATIC IMPAIRMENTAvoid in moderate to severe
impairment.
Dose adjustmentsMax. initial dose 2. 5 mg every 6 hours in
patients not currently treated with an opioid with mild
impairment.
lRENAL IMPAIRMENTOpioid effects increased and
prolonged and increased cerebral sensitivity occurs. Avoid
if estimated glomerularfiltration rate less than
10 mL/minute/ 1. 73 m^2.
Dose adjustmentsMax. initial dose 2. 5 mg every 6 hours in
patients not currently treated with an opioid with mild to
moderate impairment.
lPRESCRIBING AND DISPENSING INFORMATIONModified-
release preparations are available as 12 -hourly or
24 -hourly formulations. Preparations that should be given
12 -hourly includeAbtard®,Carexil®,Leveraxo®,Longtec®,
Oxeltra®,OxyContin®,Oxylan®,Reltebon®, and
Zomestine®. Preparations that should be given 24 -hourly
includeOnexila®XL.
Palliative careFor further information on the use of
oxycodone in palliative care, seewww.palliativedrugs.com/
formulary/en/oxycodone.html.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: oral solution, solution for infusion
Modified-release tablet
CAUTIONARY AND ADVISORY LABELS2, 25
▶Oxycodone hydrochloride (Non-proprietary)
Oxycodone hydrochloride 15 mgOxycodone 15 mg modified-release
tablets| 56 tabletP£ 38. 12 DT = £ 38. 12 b
Oxycodone hydrochloride 30 mgOxycodone 30 mg modified-
release tablets| 56 tabletP£ 76. 23 DT = £ 76. 23 b
Oxycodone hydrochloride 60 mgOxycodone 60 mg modified-
release tablets| 56 tabletP£ 152. 49 DT = £ 152. 49 b
▶Abtard(Ethypharm UK Ltd)
Oxycodone hydrochloride 5 mgAbtard 5 mg modified-release
tablets| 28 tabletP£ 6. 26 DT = £ 12. 52 b
Oxycodone hydrochloride 10 mgAbtard 10 mg modified-release
tablets| 56 tabletP£ 12. 52 DT = £ 25. 04 b
Oxycodone hydrochloride 15 mgAbtard 15 mg modified-release
tablets| 56 tabletP£ 19. 06 DT = £ 38. 12 b
Oxycodone hydrochloride 20 mgAbtard 20 mg modified-release
tablets| 56 tabletP£ 25. 04 DT = £ 50. 08 b
Oxycodone hydrochloride 30 mgAbtard 30 mg modified-release
tablets| 56 tabletP£ 38. 11 DT = £ 76. 23 b
Oxycodone hydrochloride 40 mgAbtard 40 mg modified-release
tablets| 56 tabletP£ 50. 09 DT = £ 100. 19 b
Oxycodone hydrochloride 60 mgAbtard 60 mg modified-release
tablets| 56 tabletP£ 76. 24 DT = £ 152. 49 b
Oxycodone hydrochloride 80 mgAbtard 80 mg modified-release
tablets| 56 tabletP£ 100. 19 DT = £ 200. 39 b
▶Carexil(Sandoz Ltd)
Oxycodone hydrochloride 5 mgCarexil 5 mg modified-release
tablets| 28 tabletP£ 6. 26 DT = £ 12. 52 b
Oxycodone hydrochloride 10 mgCarexil 10 mg modified-release
tablets| 56 tabletP£ 12. 52 DT = £ 25. 04 b
Oxycodone hydrochloride 20 mgCarexil 20 mg modified-release
tablets| 56 tabletP£ 25. 04 DT = £ 50. 08 b
Oxycodone hydrochloride 40 mgCarexil 40 mg modified-release
tablets| 56 tabletP£ 60. 11 DT = £ 100. 19 b
Oxycodone hydrochloride 80 mgCarexil 80 mg modified-release
tablets| 56 tabletP£ 120. 23 DT = £ 200. 39 b
▶Leveraxo(Mylan)
Oxycodone hydrochloride 5 mgLeveraxo 5 mg modified-release
tablets| 28 tabletP£ 12. 39 DT = £ 12. 52 b
Oxycodone hydrochloride 10 mgLeveraxo 10 mg modified-release
tablets| 56 tabletP£ 24. 79 DT = £ 25. 04 b
Oxycodone hydrochloride 20 mgLeveraxo 20 mg modified-release
tablets| 56 tabletP£ 49. 58 DT = £ 50. 08 b
Oxycodone hydrochloride 30 mgLeveraxo 30 mg modified-release
tablets| 56 tabletP£ 75. 47 DT = £ 76. 23 b
Oxycodone hydrochloride 40 mgLeveraxo 40 mg modified-release
tablets| 56 tabletP£ 99. 19 DT = £ 100. 19 b
Oxycodone hydrochloride 60 mgLeveraxo 60 mg modified-release
tablets| 56 tabletP£ 150. 97 DT = £ 152. 49 b
Oxycodone hydrochloride 80 mgLeveraxo 80 mg modified-release
tablets| 56 tabletP£ 198. 39 DT = £ 200. 39 b
▶Longtec(Qdem Pharmaceuticals Ltd)
Oxycodone hydrochloride 5 mgLongtec 5 mg modified-release
tablets| 28 tabletP£ 6. 26 DT = £ 12. 52 b
Oxycodone hydrochloride 10 mgLongtec 10 mg modified-release
tablets| 56 tabletP£ 12. 52 DT = £ 25. 04 b
Oxycodone hydrochloride 15 mgLongtec 15 mg modified-release
tablets| 56 tabletP£ 19. 06 DT = £ 38. 12 b
Oxycodone hydrochloride 20 mgLongtec 20 mg modified-release
tablets| 56 tabletP£ 25. 04 DT = £ 50. 08 b
Oxycodone hydrochloride 30 mgLongtec 30 mg modified-release
tablets| 56 tabletP£ 38. 11 DT = £ 76. 23 bBNFC 2018 – 2019 Pain 285
Nervous system4