lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: infusion
Powder for solution for injection
ELECTROLYTES:May contain Sodium
▶Benzylpenicillin sodium (Non-proprietary)
Benzylpenicillin sodium 600 mgBenzylpenicillin 600 mg powder for
solution for injection vials| 2 vialP£ 5. 46 DT = £ 5. 46 |
25 vialP£ 68. 25 – £ 68. 29
Benzylpenicillin sodium 1.2 gramBenzylpenicillin 1. 2 g powder for
solution for injection vials| 25 vialP£ 92. 01 – £ 92. 03 DT = £ 92. 02
eiiiiF 336
Phenoxymethylpenicillin
(Penicillin V)
lINDICATIONS AND DOSE
Oral infections|Tonsillitis|Otitis media|Erysipelas|
Cellulitis
▶BY MOUTH
▶Child 1–11 months: 62. 5 mg 4 times a day; increased if
necessary up to 12. 5 mg/kg 4 times a day
▶Child 1–5 years: 125 mg 4 times a day; increased if
necessary up to 12. 5 mg/kg 4 times a day
▶Child 6–11 years: 250 mg 4 times a day; increased if
necessary up to 12. 5 mg/kg 4 times a day
▶Child 12–17 years: 500 mg 4 times a day; increased if
necessary up to 1 g 4 times a day
Prevention of recurrence of rheumatic fever
▶BY MOUTH
▶Child 1 month–5 years: 125 mg twice daily
▶Child 6–17 years: 250 mg twice daily
Prevention of secondary case of invasive group A
streptococcal infection
▶BY MOUTH
▶Neonate: 12. 5 mg/kg every 6 hours (max. per dose
62. 5 mg) for 10 days.▶Child 1–11 months: 62. 5 mg every 6 hours for 10 days
▶Child 1–5 years: 125 mg every 6 hours for 10 days
▶Child 6–11 years: 250 mg every 6 hours for 10 days
▶Child 12–17 years: 250 – 500 mg every 6 hours for 10 days
Prevention of pneumococcal infection in asplenia or in
patients with sickle-cell disease
▶BY MOUTH
▶Child 1–11 months: 62. 5 mg twice daily
▶Child 1–4 years: 125 mg twice daily
▶Child 5–17 years: 250 mg twice daily
Acute sinusitis
▶BY MOUTH
▶Child 1–11 months: 62. 5 mg 4 times a day for 5 days
▶Child 1–5 years: 125 mg 4 times a day for 5 days
▶Child 6–11 years: 250 mg 4 times a day for 5 days
▶Child 12–17 years: 500 mg 4 times a day for 5 dayslUNLICENSED USEgDuration of treatment for acute
sinusitis adheres to national guidelines.hSee Sinusitis
(acute) p. 697 for further information.
lINTERACTIONS→Appendix 1 : penicillins
lSIDE-EFFECTSArthralgia.circulatory collapse.
coagulation disorder.eosinophilia.exfoliative dermatitis.
faeces soft.fever.increased risk of infection.
neurotoxicity.oral disorders.paraesthesia
lPREGNANCYNot known to be harmful.
lBREAST FEEDINGTrace amounts in milk, but appropriate
to use.
lEFFECT ON LABORATORY TESTSFalse-positive urinary
glucose (if tested for reducing substances).
lPATIENT AND CARER ADVICE
Medicines for Children leaflet: Penicillin V for bacterial
infectionswww.medicinesforchildren.org.uk/penicillin-v-for-
bacterial-infections
Medicines for Children leaflet: Penicillin V for prevention of
pneumococcal infectionwww.medicinesforchildren.org.uk/
penicillin-v-for-prevention-of-pneumococcal-infection
lPROFESSION SPECIFIC INFORMATION
Dental practitioners’formulary
Phenoxymethylpenicillin Tablets may be prescribed.
Phenoxymethylpenicillin Oral Solution may be
prescribed.lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Oral solution
CAUTIONARY AND ADVISORY LABELS9, 23
▶Phenoxymethylpenicillin (Non-proprietary)
Phenoxymethylpenicillin (as Phenoxymethylpenicillin potassium)
25 mg per 1 mlPhenoxymethylpenicillin 125 mg/ 5 ml oral solution|
100 mlP£ 34. 00 DT = £ 4. 97
Phenoxymethylpenicillin 125 mg/ 5 ml oral solution sugar free sugar-
free| 100 mlP£ 25. 00 DT = £ 8. 10
Phenoxymethylpenicillin (as Phenoxymethylpenicillin potassium)
50 mg per 1 mlPhenoxymethylpenicillin 250 mg/ 5 ml oral solution|
100 mlP£ 35. 00 DT = £ 7. 34
Phenoxymethylpenicillin 250 mg/ 5 ml oral solution sugar free sugar-
free| 100 mlP£ 35. 00 DT = £ 7. 99
Tablet
CAUTIONARY AND ADVISORY LABELS9, 23
▶Phenoxymethylpenicillin (Non-proprietary)
Phenoxymethylpenicillin (as Phenoxymethylpenicillin potassium)
250 mgPhenoxymethylpenicillin 250 mg tablets| 28 tabletP
£ 5. 00 DT = £ 0. 71ANTIBACTERIALS›PENICILLINS,
BROAD-SPECTRUM
eiiiiF 336Amoxicillin
(Amoxycillin)
lINDICATIONS AND DOSE
Susceptible infections (including urinary-tract infections,
otitis media, sinusitis, uncomplicated community
acquired pneumonia, salmonellosis, oral infections)
▶BY MOUTH
▶Neonate 7 days to 28 days: 30 mg/kg 3 times a day (max.
per dose 125 mg).▶Child 1–11 months: 125 mg 3 times a day; increased if
necessary up to 30 mg/kg 3 times a day
▶Child 1–4 years: 250 mg 3 times a day; increased if
necessary up to 30 mg/kg 3 times a day
▶Child 5–11 years: 500 mg 3 times a day; increased if
necessary up to 30 mg/kg 3 times a day (max. per dose
1 g)
▶Child 12–17 years: 500 mg 3 times a day; increased if
necessary up to 1 g 3 times a day, use increased dose in
severe infections
▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION
▶Neonate up to 7 days: 30 mg/kg every 12 hours, increased
if necessary to 60 mg/kg every 12 hours, increased dose
used in severe infection, community-acquired
pneumonia or salmonellosis.▶Neonate 7 days to 28 days: 30 mg/kg every 8 hours,
increased if necessary to 60 mg/kg every 8 hours,
increased dose used in severe infection, community-
acquired pneumonia or salmonellosis.
continued→BNFC 2018 – 2019 Bacterial infection 339
Infection5