BNF for Children (BNFC) 2018-2019

Medicines for Children leaflet: Amoxicillin for bacterial

infectionswww.medicinesforchildren.org.uk/amoxicillin-

bacterial-infections- 0

lPROFESSION SPECIFIC INFORMATION

Dental practitioners’formulary

Amoxicillin capsules may be prescribed. Amoxicillin

sachets may be prescribed as Amoxicillin Oral Powder.

Amoxicillin Oral Suspension may be prescribed.

lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Powder for solution for injection
ELECTROLYTES:May contain Sodium
▶Amoxicillin (Non-proprietary)
Amoxicillin (as Amoxicillin sodium) 250 mgAmoxicillin 250 mg
powder for solution for injection vials| 10 vialP£ 4. 50 – £ 4. 80
Amoxicillin (as Amoxicillin sodium) 500 mgAmoxicillin 500 mg
powder for solution for injection vials| 10 vialP£ 9. 60 – £ 12. 00 DT
=£ 5. 48
Amoxicillin (as Amoxicillin sodium) 1 gramAmoxicillin 1 g powder
for solution for injection vials| 1 vialP£ 1. 92 | 10 vialP
£ 16. 50 DT = £ 10. 96
▶Amoxil(GlaxoSmithKline UK Ltd)
Amoxicillin (as Amoxicillin sodium) 500 mgAmoxil 500 mg powder
for solution for injection vials| 10 vialP£ 5. 48 DT = £ 5. 48
Amoxicillin (as Amoxicillin sodium) 1 gramAmoxil 1 g powder for
solution for injection vials| 10 vialP£ 10. 96 DT = £ 10. 96
Oral suspension
CAUTIONARY AND ADVISORY LABELS 9
EXCIPIENTS:May contain Sucrose
▶Amoxicillin (Non-proprietary)
Amoxicillin (as Amoxicillin trihydrate) 25 mg per 1 mlAmoxicillin
125 mg/ 5 ml oral suspension sugar free sugar-free| 100 mlP
£ 25. 00 DT = £ 0. 99
Amoxicillin 125 mg/ 5 ml oral suspension| 100 mlP£ 25. 00 DT =
£ 1. 17
Amoxicillin (as Amoxicillin trihydrate) 50 mg per 1 mlAmoxicillin
250 mg/ 5 ml oral suspension sugar free sugar-free| 100 mlP
£ 35. 00 DT = £ 1. 24
Amoxicillin 250 mg/ 5 ml oral suspension| 100 mlP£ 35. 00 DT =
£ 1. 35
▶Amoxil(GlaxoSmithKline UK Ltd)
Amoxicillin (as Amoxicillin trihydrate) 100 mg per 1 mlAmoxil
125 mg/ 1. 25 ml paediatric oral suspension| 20 mlP£ 3. 18 DT =
£ 3. 18
Powder
CAUTIONARY AND ADVISORY LABELS9, 13
▶Amoxicillin (Non-proprietary)
Amoxicillin (as Amoxicillin trihydrate) 3 gramAmoxicillin 3 g oral
powder sachets sugar free sugar-free| 2 sachetP£ 15. 00 DT =
£ 9. 98
Capsule
CAUTIONARY AND ADVISORY LABELS 9
▶Amoxicillin (Non-proprietary)
Amoxicillin (as Amoxicillin trihydrate) 250 mgAmoxicillin 250 mg
capsules| 15 capsuleP£ 5. 00 DT = £ 0. 43 | 21 capsuleP
£ 8. 99 DT = £ 0. 60 | 500 capsuleP£ 14. 29 – £ 120. 00
Amoxicillin (as Amoxicillin trihydrate) 500 mgAmoxicillin 500 mg
capsules| 15 capsuleP£ 7. 50 DT = £ 0. 56 | 21 capsuleP
£ 15. 00 DT = £ 0. 78 | 100 capsuleP£ 3. 71 – £ 75. 00
▶Amoxil(GlaxoSmithKline UK Ltd)
Amoxicillin (as Amoxicillin trihydrate) 250 mgAmoxil 250 mg
capsules| 21 capsuleP£ 0. 92 DT = £ 0. 60
Amoxicillin (as Amoxicillin trihydrate) 500 mgAmoxil 500 mg
capsules| 21 capsuleP£ 0. 89 DT = £ 0. 78
Combinations available:Co-amoxiclav,p. 343

eiiiiF 336

Ampicillin

lINDICATIONS AND DOSE

Susceptible infections (including bronchitis, urinary-tract

infections, otitis media, sinusitis, uncomplicated

community-acquired pneumonia, salmonellosis)

▶BY MOUTH

▶Neonate 7 days to 20 days: 30 mg/kg 3 times a day (max.

per dose 125 mg).

▶Neonate 21 days to 28 days: 30 mg/kg 4 times a day (max.

per dose 125 mg).

▶Child 1–11 months: 125 mg 4 times a day; increased if

necessary up to 30 mg/kg 4 times a day

▶Child 1–4 years: 250 mg 4 times a day; increased if

necessary up to 30 mg/kg 4 times a day

▶Child 5–11 years: 500 mg 4 times a day; increased if

necessary up to 30 mg/kg 4 times a day (max. per dose

1 g)

▶Child 12–17 years: 500 mg 4 times a day; increased if

necessary to 1 g 4 times a day, use increased dose in

severe infection

▶BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION

▶Neonate up to 7 days: 30 mg/kg every 12 hours, increased

if necessary to 60 mg/kg every 12 hours, increased dose

used in severe infection, community-acquired

pneumonia or salmonellosis.

▶Neonate 7 days to 20 days: 30 mg/kg every 8 hours,

increased if necessary to 60 mg/kg every 8 hours,

increased dose used in severe infection, community-

acquired pneumonia or salmonellosis.

▶Neonate 21 days to 28 days: 30 mg/kg every 6 hours,

increased if necessary to 60 mg/kg every 6 hours,

increased dose used in severe infection, community-

acquired pneumonia or salmonellosis.

▶Child: 25 mg/kg every 6 hours (max. per dose 500 mg

every 6 hours), increased if necessary to 50 mg/kg every

6 hours (max. per dose 1 g every 6 hours), increased

dose used in severe infection

Group B streptococcal infection|Enterococcal

endocarditis (in combination with another antibacterial)

▶BY INTRAVENOUS INFUSION

▶Neonate up to 7 days: 50 mg/kg every 12 hours.

▶Neonate 7 days to 20 days: 50 mg/kg every 8 hours.

▶Neonate 21 days to 28 days: 50 mg/kg every 6 hours.

▶Child: 50 mg/kg every 4 – 6 hours (max. per dose 2 g

every 4 hours)

Listerial meningitis

▶BY INTRAVENOUS INFUSION

▶Neonate up to 7 days: 100 mg/kg every 12 hours.

▶Neonate 7 days to 20 days: 100 mg/kg every 8 hours.

▶Neonate 21 days to 28 days: 100 mg/kg every 6 hours.

▶Child: 50 mg/kg every 4 – 6 hours (max. per dose 2 g

every 4 hours)

lCAUTIONS

GENERAL CAUTIONSAcute lymphocytic leukaemia

(increased risk of erythematous rashes).chronic

lymphocytic leukaemia (increased risk of erythematous

rashes).cytomegalovirus infection (increased risk of

BNFC 2018 – 2019 Bacterial infection 341

Infection

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